google-scholar

Kompella, U.B., Singh, S.R., and Sundaram, S. Methods and compositions for targeted delivery of therapeutic agents (Compositions and methods for targeted delivery of therapeutic agents, and particularly for mucosal, oral, nasal, or parenteral delivery of therapeutic agents. The compositions comprise carrier particles containing or encapsulating a therapeutic agent or agents, which have been modified on their surface to contain one or more targeting moieties that enable the enhanced uptake and transport of the therapeutic agent via receptor-mediated processes such as endocytosis or transcytosis. Compositions include functionalized nanoparticles for enhanced invasive delivery or noninvasive delivery to the back of the eye). International Patent Application. 12/09/2007. WO/2008/033924.

Tari, S.R., Gaetano, B.R., and Kompella, U.B. Polychromatic, diversely-sized particles for angiography (The invention involves polychromatic particles of various sizes for assessing blood flow, blood barrier leakage and blood vessel leakage. Nanoparticle compositions are disclosed to diagnose the vessel types affected in vascular disorders of the eye. These nanoparticles are useful to quantify and diagnose the disease state). International Patent Application. 06/07/2007. WO/2008/005514.​

google-patents

  
Rinku Baid
Graduate Student
Phone: 303-724-4026
Rinku’s graduate research focuses on the development of novel protein delivery system that can be used for the treatment of retinal degenerative diseases.​​​
Kristen Grompone
Professional Research Assistant
Phone: 303-724-5288
Kristen’s research focuses on the use of noninvasive monitoring of therapeutics delivered to the eye. She is also responsible for maintaining the administrative aspects of the Kompella lab.​​​
Vidhya Rao
Post Doctoral Fellow
Phone: 303-724-4026
Vidhya’s research focuses on the development of therapeutics for diabetic retinopathy.

Publications
  1. Rao, V.R., Prescott, E., Shelke, N., Trivedi, R., Thomas, P., Struble, C., Gadek, T., O’Neill, C.A., Kompella, U.B.* Delivery of SAR 1118 to retina via ophthalmic drops and its effectiveness in reduction of retinal leukostasis and vascular leakiness in rat streptozotocin (STZ) model of diabetic retinopathy (DR). Invest. Ophthalmol. Vis. Sci. (submitted).
Sneha Sundaram
Post Doctoral Fellow
Phone: 303.724.5288
Sneha’s research focuses on the use of Deslorelin functionalized nanosystems for anti-cancer drug and gene delivery.

Publications
  1. Sundaram, S., Durairaj, C., Ambati, B.K., Rajagopal, R., and Kompella, U.B.* Targeted drug and gene delivery systems for lung cancer therapy. Clin. Cancer Res. 15(23):7299-7308 (2009). PMID: 19920099.
  2. Sundaram, S., Roy, S.K., Ambati, B.K., and Kompella, U.B.* Surface functionalized nanoparticles for targeted gene delivery across nasal respiratory epithelium. FASEB J. 23(11):3752-3765 (2009).
  3. Sundaram, S., Durairaj, C., Kadam, R., and Kompella, U.B.* Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy. Mol. Cancer Ther. 8(6):1655-1665 (2009).
  4. Sundaram, S., Roy, S.K., Kompella, U.B.* Differential expression of LHRH-receptor in bovine nasal tissue and its role in deslorelin delivery. Peptides. 30(2):351-358 (2009).
  5. Kompella, U.B.*, Sundaram, S., Raghava, S., and Escobar, E. Functionalizations enhance nanoparticles delivery in a novel bovine ex vivo eye model. Mol. Vis. 12: 1185-1198 (2006).
  6. Sundaram, S., Bontha, S. S., and Kompella, U.B.* Respiratory delivery of deslorelin, a peptide drug. Am. Pharm. Rev. 7(5):130-139 (2004).
  7. Amrite, A.A., Cheruvu, N.P.S., Sundaram, S., Aravalli, R.N., Cheng, P-W, and Kompella, U.B.* Lung Gene Therapy: Clinical and Regulatory Issues. Clin. Res. Reg. Affairs 21:1-28 (2004).
Ashish Thakur
Research Staff
Phone: 303-724-4026
Ashish’s research focuses on the development of prodrugs for posterior ocular disorders.​​​
Ruchit Trivedi
Graduate Student
Phone: 303-724-4026
Ruchit’s research focuses on the development of nanosystems for drug delivery to the lungs for the treatment of cancer.

Publications
  1. Rao, V.R., Prescott, E., Shelke, N., Trivedi, R., Thomas, P., Struble, C., Gadek, T., O’Neill, C.A., Kompella, U.B.* Delivery of SAR 1118 to retina via ophthalmic drops and its effectiveness in reduction of retinal leukostasis and vascular leakiness in rat streptozotocin (STZ) model of diabetic retinopathy (DR). Invest. Ophthalmol. Vis. Sci. (submitted).
  2. Trivedi, R. and Kompella, U.B.* Nanomicellar formulations for sustained drug delivery: Strategies and underlying principles. Nanomedicine (submitted).
  3. Sundaram S, Trivedi R, Durairaj C, Ramesh R, Ambati BK, Kompella UB. Targeted drug and gene delivery systems for lung cancer therapy. Clin Cancer Res. 2009 Dec 1;15(23):7299-308. Epub 2009 Nov 17. PubMed PMID: 19920099; PubMed Central PMCID: PMC2787834.​
Puneet Tyagi
Graduate Student
Phone: 303.724.4026
Puneet’s research focuses on the efficacy of Tumstatin in treating choroidal neovascularization of the eye.​​
Sunil Vooturi
Post Doctoral Fellow
Phone: 303-724-4026
Sunil’s research focuses on the development, design, and synthesis of prodrugs for improving the transport into the posterior region of the eye.​​

Equipment available for experimental use in the Kompella lab includes:

  • Tonopen Applantation Tonometer: 532 nm diode laser
  • Ophthalmoscope and Slit Lamp
  • Probe Sonicator with controllable power input
  • Supercritical Fluid Apparatus: custom assembled
  • Waters HPLC system: autoinjector, two pumps, a photodiode array detector, a fluorescence detector, and a controller
  • LC/MS/MS system with an Agilent LC unit
  • Buchi rotavapor R-200
  • 12 Ussing chambers
  • MaxQ 4000 Metabolic Shaker Incubator
    • programmable incubation from 0 to 60 °C
    • hacking speed ranging from 0-400 rpm
  • Dual voltage-clamp unit
  • Strip-chart recorder
  • Temperature-controlled shaking water bath
  • Temperature-controlled incubators (2)
  • N-evap unit
  • Digital Analytical Balance
  • Laminar flow hoods (3)
  • Humidified CO2 incubators (2)
  • Leica microscope
  • Spectramax M5 multi-detection plate reader with triple-mode cuvette port
  • Zetasizer Nano
  • Fluorotron Master