The Translational Bio-Nanosciences Laboratory (TBNL) is pursuing the following directions using a variety of multidisciplinary approaches:
We value random discovery, serendipity, and power of observation. At the same time, we pursue systematic studies using a variety of methodologies, from serum biochemistry, to in vivo pharmacology to population studies in healthy persons and in patients. We are always looking for enthusiastic and energetic individuals.
|Guankui Wang, PhD, Postdoctoral Associate|
Guankui Wang received a bachelor’s degree in Animal Science from Northwest Agriculture and Forestry University of China in 2007. He completed his PhD in Animal Physiology from the University of Idaho in 2012. After one-year postdoctoral training in the Department of Chemistry and Biochemistry at the University of Colorado Boulder, he joined the Simberg Lab as a Postdoctoral Fellow in November 2013. He has been working on multiple projects on the development of iron oxide nanoparticles for targeted drug delivery and magnetic resonance imaging, the interactions of nanoparticles with the immune system, the isolation of circulating tumor cells from cancer patients’ blood, and cell-based therapy for leukemia.
|Ernest Groman, PhD|
Dr. Groman, possibly the oldest postdoc on campus, earned a BS in mathematics from the University of North Carolina-Chapel Hill and a PhD in biochemistry from the University of California-Berkeley. After postdoctoral studies at Massachusetts General Hospital and Harvard Medical School, he cofounded Advanced Magnetics and BioPhysics Assay Laboratory. He is the lead inventor of Feraheme, a drug used to treat iron deficiency anemia and as an experimental MRI contrast agent to study inflammation (following chemotherapy), vascular disease and lymphatic involvement in various cancers. His interests include translation of grant funded projects into products, drug delivery using nanoparticles, cell labeling with nanoparticles, development of dual label contrast agents and applications of magnetic fields to improve drug delivery.
|Hanman Gaikwad, PhD|
Hanmant Gaikwad received a Master degree (M.Sc.) in Organic Chemistry from the Shivaji University, Kolhapur in 2005. He completed his PhD in Organic and Medicinal Chemistry from the CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India in 2013. Later, in 2013, he joined as a Post-doctoral researcher in Dr. Galia Blum's research group at School of Pharmacy, Hebrew University, Jerusalem. He worked on molecular imaging of cancer using X‑ray computed tomography with protease targeted iodinated activity-based probes. Then he joined the Simberg Lab as a postdoctoral Associate in December 2017. His research work focuses on development of new class of small molecules, nanoparticle conjugates, lipid conjugates and antibody conjugates with cleavable linkers for targeted drug delivery and molecular imaging.
|Laren Lofchy, PhD Candidate|
Laren Lofchy, graduate student. She received her Bachelors’ of Science and Engineering (BSE) in Chemical Engineering from the University of Michigan in 2017 and joined the Simberg lab as a PhD student soon after. She is currently researching the mechanism of nanoparticle extravasation with the hope of one day exploiting it. If she had free time, she’d be found skiing, backpacking, or composing experimental electronic music.
|Geoffrey Gifford, BSc, Professional Research Assistant|
|Fangfang Chen, PhD, Visiting Research Professor (Jilin University, China)|
|Chunyan Yang, MD, PhD, Visiting Scholar |
Dr. Yang was born in February 1980. She got the Master’s degree in Internal Medicine of Jilin University in June 2008 and the Doctor's degree of Jilin University in June 2012. Since August 2012, she has been an attending physician in the department of cardiology of China-Japan Union Hospital of Jilin University.
She likes reading newspapers, magazines and works of literature, etc. By doing so, she learns about the wonderful world and enriches her spiritual world.
|Ping Ren, MD, PhD, Visiting Scholar |
Dr. Ren is a practicing surgeon in the Department of Thoracic Surgery, the first hospital of Jilin University. He received his PhD and MD from Jilin University.
|Paulina Do, PharmD Candidate|
|Weston Smith, PhD, Postdoctoral Associate|
|Vivian Vu, Professional Research Assistant|
|Huy Tran, Undergraduate Bioengineering Program, CU Boulder|
|James Griffin, BSc., Research Associate|
|Abilash (Abi) Prabhakaran, Cherry Creek High School Student|
|Barbara Brenneman, BSc, PharmD Candidate|
|Jessica Jones, BSc, PharmD Candidate|
|Halli Benasutti, BSc, Research Assistant|
|Hye Hyun (Sally) Kim, undergraduate student|
Chemical and Biological Engineering
University of Colorado Boulder
|Swetha Inturi, PhD, Postdoctoral Associate|
|Christopher Bull, PharmD Candidate Student|
|Rajesh Mukthavaram, PhD, Postdoctoral Scholar|
|Guixin Shi, PhD, Postdoctoral Scholar|
|Wenjin Cui, PhD, Postdoctoral Scholar|
|Amose Kim, BS, Research Assistant|
|Kevin Cheng, BSc, Research Assistant|
|Ritish Mittal, BSc, Research Assistant|
|Laura Restrepo, MSc, Research Assistant|
Advice for Scientists
We are a green lab!
We believe that whatever we do in the lab has an environmental price. We do science, which is a cool thing, and it benefits humankind. However, science can take a serious environmental toll. For example, each chemical hood uses as much energy as the average American household. The chemicals that we order and synthesize in the lab also use a lot of energy to make them. And chemicals that aren’t discarded properly can pollute water sources and kill marine life.
So, in our lab, we strive to be sustainable and have embraced the Reduce, Reuse, and Recycle model to be an environmentally responsible as possible. Here are some common tips we use in our lab that you could use, too: