ProfessorDirector of Innovation and Commercialization, Director of Entrepreneurship Education, SPARK/REACH Program, Director of the Center of Excellence Program for Model Informed Drug Development
Department of Pharmaceutical Sciences
Research Focus:BiomarkersDiscovery and Translation of Novel Treatment Approaches to Kidney DiseasesDrug-induced kidney toxicitiesGenetics of drug efficacy and toxicityIn Vivo and In Vitro Drug Metabolism and Transport in KidneyInnovation and entrepreneurshipPharmacokinetics and PharmacodynamicsPreclinical and clinical development of drugs and biologics
Colorado Center for Nanomedicine and Nanosafety Co-Director and Co-founderProfessor of Pharmaceutical Sciences, Ophthalmology, and Bioengineering
Department of Pharmaceutical Sciences
Research Focus:Nanomedicines for drug delivery gene delivery and imagingNovel drug delivery systems: Nanoparticles microparticles and implants.Novel therapies for diabetic retinopathy macular degeneration and cancers.Ocular respiratory and brain drug discovery delivery and development
ProfessorDirector CU AMC Center for Drug Discovery, Co-Director, Drug Discovery and Development Shared Resource (D3SR)
Department of Pharmaceutical Sciences
Research Focus:Drug DesignDrug Mechanism(s) of ActionHTS/HCS Drug DiscoveryIn vitro and In vivo Pharmacokinetics and ToxicologyIn vitro and In vivo PharmacologyMolecular and Cancer BiologyOrganic and Medicinal Chemistry
Professor, Pharmaceutical Sciences Graduate Program Associate Director
Department of Pharmaceutical Sciences
Research Focus:Biophysical characterization of protein vaccine stability and aggregationStructure stability and aggregation of protein drug substances and drug productsStructure-function-disease analysis of dystrophin and muscular dystrophy
Assistant ProfessorToxicology Graduate Program Associate Director
Department of Pharmaceutical Sciences
Research Focus:Complement-mediated tissue damageExtracellular vesicles and organ-organ crosstalkImmunotherapy and natural immunosuppressionInnate immunity and chronic liver diseases
Associate Dean for Research and Graduate Studies, Professor
Department of Pharmaceutical Sciences
Research Focus:Environmental causes of neuronal injuryMitochondrial (dys)function and oxidative stress in epilepsy and neurodegenerationNeuroinflammation and redox signalingRedox-based small molecule therapeutics
ProfessorComputational Chemistry and Biology Core Facility Director
Department of Pharmaceutical Sciences
Research Focus:Chemical synthesis of heterocyclic compoundsComputational-based design of novel small moleculesDisrupting drug resistance mechanisms in cancer (DNA damage response)Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)
Research Focus:Metabolomics lipidomics and proteomicsNovel informatics strategies applied to metabolomicsNutrimetabolomicsRole of oxylipins in inflammatory immune and lung diseaseUnderstanding role of host:microbiome metabolism in health and disease
Research Focus:Environmental causes of neurodegeneration e.g. maneb exposureMetabolic consequences of mitochondrial dysfunctionProteostasis and neurodegenerationThiol redox dysregulation in mechanisms of toxicity
Research Focus:Genetics of substance use disordersMulti-omics data integrationStatistical methods and bioinformatics techniques for studying complex genetic traitsTranscriptomics and systems genetics