Pharmaceutical Sciences Faculty

Research Focus: Drug Design Drug Mechanism(s) of Action HTS/HCS Drug Discovery In vitro and In vivo Pharmacokinetics and Toxicology In vitro and In vivo Pharmacology Molecular and Cancer Biology Organic and Medicinal Chemistry

Research Focus: cytochrome P450 enzymes drug metabolism and disposition enzymology Pharmacokinetics

Research Focus: 2D NMR spectroscopy of antibody therapeutics Biophysical characterization of protein vaccine stability and aggregation Structure stability and aggregation of protein drug substances and drug products Structure-function-disease analysis of dystrophin and muscular dystrophy

Research Focus: Complement-mediated tissue damage Extracellular vesicles and organ-organ crosstalk Immunotherapy and natural immunosuppression Innate immunity and chronic liver diseases

Research Focus: Environmental causes of neuronal injury Mitochondrial (dys)function and oxidative stress in epilepsy and neurodegeneration Neuroinflammation and redox signaling Redox-based small molecule therapeutics

Research Focus: Ecological Roles of Natural Products Host-Microbiome-Environment Interactions Mass Spectrometry Tools for Microbial Systems

Research Focus: Behavioral responses to alcohol Quantitative RNA sequencing Systems genetics

Research Focus: Chemical synthesis of heterocyclic compounds Computational-based design of novel small molecules Disrupting drug resistance mechanisms in cancer (DNA damage response) Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)

Research Focus: Metabolomics lipidomics and proteomics Novel informatics strategies applied to metabolomics Nutrimetabolomics Role of oxylipins in inflammatory immune and lung disease Understanding role of host:microbiome metabolism in health and disease

Research Focus: Environmental causes of neurodegeneration e.g. maneb exposure Metabolic consequences of mitochondrial dysfunction Proteostasis and neurodegeneration Thiol redox dysregulation in mechanisms of toxicity

Research Focus: Genetics of substance use disorders Multi-omics data integration Statistical methods and bioinformatics techniques for studying complex genetic traits Transcriptomics and systems genetics

Research Focus: Immunology and nanoformulations/drug delivery systems Molecular biology immunology and nanotechnology

Research Focus: Cells as carriers of drugs and diagnostics Immune recognition of nanoparticles Isolation of biomarkers and cells from bulk fluids