Pharmaceutical Sciences Faculty

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2D NMR spectroscopy of antibody therapeutics
Antiviral drug pharmacokinetic-pharmacodynamic relationships in humans
Autism Spectrum Disorders and Epilepsy
Autoantigen discovery in autoimmune diseases
Behavioral responses to alcohol
biomarkers
Biomarkers
Biophysical characterization of protein vaccine stability and aggregation
Biophysical characterization of therapeutic macromolecules
Bladder Cancer
Cancer Biology
Cancer Pharmacology
Cancer Pharmacology of Natural Products
CAR T and engineered T cell therapies of autoimmune diseases
Cardiovascular Diseases
Cells as carriers of drugs and diagnostics
Chemical synthesis of heterocyclic compounds
Chronic kidney disease of unknown origin (CKDu)
Clinical Pharmacogenomics
Complement-mediated tissue damage
Computational chemistry
Computational-based design of novel small molecules
Creating extensive DNA and RNA sequence information for rat strains to be used in systems analysis of physiology and behavior
cytochrome P450 enzymes
Developing novel technology to improve drug oral bioavailability
Development of medications to be used for prevention of relapse in alcoholics
Development of medications to treat chronic pain syndromes and reduce opiate use
Development of software solutions
Discovery and Translation of Novel Treatment Approaches to Kidney Diseases
Disrupting drug resistance mechanisms in cancer (DNA damage response)
Drug Design
Drug Mechanism(s) of Action
drug metabolism and disposition
drug-drug interactions
Drug-induced kidney toxicities
Ecological Roles of Natural Products
Environmental causes of neurodegeneration e.g. maneb exposure
Environmental causes of neuronal injury
enzymology
Examination of social learning and behaviors in the autistic brain
Extracellular vesicles and organ-organ crosstalk
Genetics of drug efficacy and toxicity
Genetics of substance use disorders
Heart Transplantation
HIV
Host-Microbiome-Environment Interactions
HTS/HCS Drug Discovery
Identifying new bio-analytical methodology
Immune recognition of nanoparticles
Immunology and nanoformulations/drug delivery systems
Immunotherapy and natural immunosuppression
In vitro and In vivo Pharmacokinetics and Toxicology
In vitro and In vivo Pharmacology
In Vivo and In Vitro Drug Metabolism and Transport in Kidney
In vivo electrophysiology of brain activity
Inflammation and immune responses to particulates
Inhibitory neurotransmission in health and disease
Innate immunity and chronic liver diseases
Innovation and entrepreneurship
Isolation of biomarkers and cells from bulk fluids
Mass spectrometry
Mass Spectrometry Tools for Microbial Systems
Mast cells and allergy
Mathematical modeling of pharmacokinetic data
Mechanisms of alcoholic liver disease
Mechanisms of plasticity in the developing brain
Mechanisms of T cell mediated metal hypersensitivities
Mechanisms of T cell recognition of autoantigens in Type 1 diabetes and RA
Mechanisms of transcriptional regulation
Medicinal Chemistry - rational drug design and Structure-Activity Relationship (SAR) elucidation
Metabolic consequences of mitochondrial dysfunction
Metabolic dysregulation of liver and kidney function
Metabolomics lipidomics and proteomics
Mitochondrial (dys)function and oxidative stress in epilepsy and neurodegeneration
Molecular and Cancer Biology
Molecular biology immunology and nanotechnology
Multi-omics data integration
Nanomedicine and Nanosafety
Nanomedicines for drug delivery gene delivery and imaging
Neuroinflammation and redox signaling
New assays for drug/metabolite quantification in unique compartments in humans
Novel drug delivery systems: Nanoparticles microparticles and implants.
Novel informatics strategies applied to metabolomics
Novel therapies for diabetic retinopathy macular degeneration and cancers.
Nutrimetabolomics
Ocular respiratory and brain drug discovery delivery and development
Organic and Medicinal Chemistry
Pathogenesis of Type 1 Diabetes
pediatrics
Pharmacokinetics
Pharmacokinetics and Pharmacodynamics
Post-translational modifications
Preclinical and clinical development of drugs and biologics
pregnant women
Proteostasis and neurodegeneration
Public Science Communication
Quantitative RNA sequencing
Redox signaling and drug design in the immune diseases and infectious diseases
Redox-based small molecule therapeutics
Regulatory nature of sirtuin activity and protein acetylation
Role of oxylipins in inflammatory immune and lung disease
Science and Medical Journalism
Statistical methods and bioinformatics techniques for studying complex genetic traits
Structure stability and aggregation of protein drug substances and drug products
Structure-function-disease analysis of dystrophin and muscular dystrophy
Systems genetics
T cell immunology
Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)
The genetic predisposing factors for alcoholism and other addictions
Thermodynamics of protein-protein and protein-DNA interactions
Thiol redox dysregulation in mechanisms of toxicity
Transcriptomics and systems genetics
tuberculosis
Understanding role of host:microbiome metabolism in health and disease
Using drug concentrations to assess adherence to antiviral therapies
Utilizing mass spectrometry to investigate proteomics & post-translational modifications
Warfare vesicants

Rebecca McCullough PhD

Assistant Professor Toxicology Graduate Program Associate Director

Department of Pharmaceutical Sciences

Research Focus: Complement-mediated tissue damage Extracellular vesicles and organ-organ crosstalk Immunotherapy and natural immunosuppression Innate immunity and chronic liver diseases

Email:rebecca.mccullough@cuanschutz.edu

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Susan Mitchell

Professional Research Assistant

Email:susan.mitchell@cuanschutz.edu

Morgan Nebbia

Professional Research Assistant

Email:morgan.nebbia@cuanschutz.edu

Manisha Patel PhD

Associate Dean for Research and Graduate Studies, Professor

Department of Pharmaceutical Sciences

Research Focus: Environmental causes of neuronal injury Mitochondrial (dys)function and oxidative stress in epilepsy and neurodegeneration Neuroinflammation and redox signaling Redox-based small molecule therapeutics

Email:manisha.patel@cuanschutz.edu

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Vanessa Phelan PhD

Assistant Professor

Department of Pharmaceutical Sciences

Research Focus: Ecological Roles of Natural Products Host-Microbiome-Environment Interactions Mass Spectrometry Tools for Microbial Systems

Email:vanessa.phelan@cuanschutz.edu

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Richard Radcliffe PhD

Professor

Department of Pharmaceutical Sciences

Research Focus: Behavioral responses to alcohol Quantitative RNA sequencing Systems genetics

Email:richard.radcliffe@cuanschutz.edu

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Philip Reigan PhD

Associate Professor Computational Chemistry and Biology Core Facility Director

Department of Pharmaceutical Sciences

Research Focus: Chemical synthesis of heterocyclic compounds Computational-based design of novel small molecules Disrupting drug resistance mechanisms in cancer (DNA damage response) Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)

Email:philip.reigan@cuanschutz.edu

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Nichole Reisdorph PhD

Professor Mass Spectrometry Facility Director

Department of Pharmaceutical Sciences

Research Focus: Metabolomics lipidomics and proteomics Novel informatics strategies applied to metabolomics Nutrimetabolomics Role of oxylipins in inflammatory immune and lung disease Understanding role of host:microbiome metabolism in health and disease

Email:nichole.reisdorph@cuanschutz.edu

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Madison Ricco PharmD

Post-Doctoral Academic Fellow

Distance Degrees and Programs Department of Clinical Pharmacy

Email:madison.ricco@cuanschutz.edu

James Roede PhD

Associate Professor

Department of Pharmaceutical Sciences

Research Focus: Environmental causes of neurodegeneration e.g. maneb exposure Metabolic consequences of mitochondrial dysfunction Proteostasis and neurodegeneration Thiol redox dysregulation in mechanisms of toxicity

Email:james.roede@cuanschutz.edu

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Laura Saba PhD

Associate Professor Director

Department of Pharmaceutical Sciences

Research Focus: Genetics of substance use disorders Multi-omics data integration Statistical methods and bioinformatics techniques for studying complex genetic traits Transcriptomics and systems genetics

Email:laura.saba@cuanschutz.edu

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