My research interests are broad. My expertise is in the areas of molecular biology, immunology, and nanotechnology. Currently, I have two major research projects. I am collaborating with Dmitri Simberg on topics relating to immunology and nanoformulations/drug delivery systems. The body can view the surface of a nanoparticle as foreign and react to it. The second major project involves a collaboration with Dr. Andrew Monte in the department of Emergency Medicine. Dr. Monte is an MD with an expertise in drugs of abuse.
Education, Licensure & Certifications
- BS, Massachusetts Institute of Technology (Biology)
- PhD, University of Washington, Seattle (Pharmacology)
Affiliations
- Member, University of Colorado Cancer Center
Research Interest
- Immunology and nanoformulations/drug delivery systems
- Molecular biology immunology and nanotechnology
Publications and Presentations
- Williams-Skipp, C., Raman, T., Valuck, R.J., Watkins, H., Palmer, B.E., and Scheinman, R.I. (2009) Unmasking of a Protective TNFR1 Mediated Signal in the Collagen Arthritis Model. Arthritis Rheum. 60(2):408-18
- Scheinman, RI, Trivedi, R, Vermillion, S, Kompella, U (2011) RGD-Functionalized STAT1 siRNA Nanoparticles Regress Rheumatoid Arthritis in a Mouse Model. Nanomedicine (London) 6(10):1669-1682.
- Mehta, G, Scheinman, RI, Holers, VM, Banda NK. (2015) A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5R1 Antibody and C5 Small Interfering RNA. J. Immunol. 194(11):5446-54
- Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D. (2019) Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nature Nanotechnology 14(3):260-268.