Dr. Laura Saba is an Associate Professor of Bioinformatics in the Department of Pharmaceutical Sciences of the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus. She also has a secondary appointment in the Department of Biostatistics and Informatics at the Colorado School of Public Health, she is part of the Computation Bioscience Program at CU Anschutz, she is a member of the Training Faculty for the Pharmacology Program within the CU School of Medicine and she is a fellow at the Institute for Behavioral Genetics at CU Boulder. She received her Bachelor of Science in Chemistry from Colorado School of Mines and her PhD in Biostatistics from the University of Colorado Health Science Center under the supervision of Dr. Diane Fairclough. She has almost 20 years of experience applying state-of-the-art statistical methodology to health-related studies including genetic, genomic, and proteomic studies of complex traits. Her research focuses on applying systems genetics techniques to high-throughput data to build predictive models.
Education, Licensure & Certifications
- BS in Chemistry, Colorado School of Mines, Golden, CO
- PhD in Biostatistics, University of Colorado Health Science Center (currently Colorado School of Public Health), Denver, CO
Awards
- 2022 - Excellence in Pharmaceutical Sciences Doctoral Teaching Award; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus
- 2020 - Faculty Excellence in Mentoring and Advising; Colorado School of Public Health, University of Colorado Anschutz Medical Campus
- 2019 - Alumni member - Delta Omega National Honorary Society in Public Health; Colorado School of Public Health, University of Colorado Anschutz Medical Campus
- 2019 - PhD Alumni Award; Graduate School, University of Colorado Anschutz Medical Campus
Affiliations
- Fellow - Institute for Behavioral Genetics; University of Colorado | Boulder
- Core Faculty - Computational Bioscience Program; University of Colorado | Anschutz Medical Campus
- Training Faculty - Pharmacology PhD Program; University of Colorado | Anschutz Medical Campus
- Secondary Appointment - Department of Biostatistics and Informatics; Colorado School of Public Health
Courses
Course Director/Primary Instructor:
- Applied Statistics for Toxicology & Pharmaceutical Sciences (PHSC/TXCL 7565)
Lecturer:
- Fundamentals of Pharmaceutical Sciences (PHSC/TXCL 7310)
- Ethical Issues in Toxicology & Pharmaceutical Sciences (TXCL/PHSC 7400)
- Methods and Tools in Biomedical Informatics (CPBS 7711)
- Evidence-based Medicine and Literature Evaluation (PHRD 6065)
Research Interest
- Genetics of substance use disorders
- Multi-omics data integration
- Statistical methods and bioinformatics techniques for studying complex genetic traits
- Transcriptomics and systems genetics
Publications and Presentations
Seal S, Li Q, Basner EB, Saba LM, Kechris K. RCFGL: Rapid Condition adaptive Fused Graphical Lasso and application to modeling brain region co-expression networks. PLoS Comput Biol. 2023 Jan 6;19(1):e1010758.
Lusk R, Hoffman PL, Mahaffey S, Rosean S, Smith H, Silhavy J, Pravenec M, Tabakoff B, Saba LM. Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel. Front Genet. 2022 Mar 15;13:821026. PMID: 35368676; PMCID: PMC8965255.
Lusk R, Stene E, Banaei-Kashani F, Tabakoff B, Kechris K, and Saba LM. Aptardi accurately incorporates expressed polyadenylation sites into sample-specific transcriptomes using a multi-omics deep learning approach. Nat Commun. 2021 Mar 12;12(1):1652.
Saba LM, Hoffman PL, Homanics GE, Mahaffey S, Daulatabad SV, Janga SC, Tabakoff B. A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats. Genes Brain Behav. 2021 Feb;20(2):e12698.