The theme of my research program is the investigation of how an exposure to a single environmental agent, such as the fungicide maneb, augments the transport and cytotoxic properties of pharmaceuticals, dietary components, and/or chemicals arising from the environment or microbiome. Elucidation of these mechanisms will help to prevent exacerbated toxicity due to alterations in gene expression resulting in enhanced transport of toxicants and xenobiotic interactions. This mechanism may be directly relevant to neurodegenerative diseases like Parkinson’s disease and neurodevelopmental diseases like autism. The aim of the laboratory is to utilize both targeted and systems approaches, such as proteomics, metabolomics and epigenomics, to investigate mechanisms of toxicity.
Education, Licensure & Certifications
- BS, Michigan State University
- PhD, University of Colorado (Advisor, Dennis R. Petersen)
- Postdoctoral Fellow, Emory University (Mentor, Dean P. Jones)
Research Interest
- Environmental causes of neurodegeneration e.g. maneb exposure
- Metabolic consequences of mitochondrial dysfunction
- Proteostasis and neurodegeneration
- Thiol redox dysregulation in mechanisms of toxicity
Publications and Presentations
Anderson C.C., Aivazidis S., Kuzyk C.L., Jain A., and Roede J.R. Acute maneb exposure disrupts both glycolysis and mitochondrial function in SK-N-AS human neuroblastoma cells. Toxicol Sci. 165(1): 61-73 2018 PMID: 29767788
Maclean K.N., Jiang H., Aivazidis S., Kim E., Shearn C.T., Harris P.S., Petersen D.R., Allen R.H., Stabler S.P., and Roede J.R. Taurine treatment prevents derangement of the hepatic gamma-glutamyl and methylglyoxal metabolism in a mouse model of classical homocystinuria: Regulatory cross-talk between thiol and sulfinic acid metabolism. FASEB J. 32(3): 1265-1280 2018 PMID: 29101223
Aivazidis S, Coughlan C.M., Rauniyar A.K., Jiang H., Liggett L.A., Maclean K.N. and Roede J.R. The burden of trisomy 21 disrupts the proteostasis network in Down syndrome. PLoS ONE. 12(4): e0176307 2017 PMID: 28430800