Research Focus:Exploiting exosome biologyImmune response to nanoparticle administrationLyophilization and stabilityNanoparticle-mediated gene deliverySmall molecule formulation
Research Focus:Antiviral drug pharmacokinetic-pharmacodynamic relationships in humansNew assays for drug/metabolite quantification in unique compartments in humansUsing drug concentrations to assess adherence to antiviral therapies
Research Focus:Biophysical characterization of therapeutic macromoleculesMechanisms of transcriptional regulationThermodynamics of protein-protein and protein-DNA interactions
ProfessorToxicology Graduate Program Director, T32 Training Program in Molecular and Systems Toxicology Director, Colorado Center for Nanomedicine and Nanosafety Co-Director
Research Focus:Bladder CancerChronic kidney disease of unknown origin (CKDu)Inflammation and immune responses to particulatesMast cells and allergyNanomedicine and Nanosafety
Research Focus:Assembly and maturation of viral capsidsMolecular mechanisms of viral DNA packaging motorsPhysical VirologyViral capsids as designer nanoparticles for therapeutic and diagnostic (theranostic) applications
Research Focus:CAR T and engineered T cell therapies of autoimmune diseasesMechanisms of T cell mediated metal hypersensitivitiesMechanisms of T cell recognition of autoantigens in Type 1 diabetes and RARedox signaling and drug design in the immune diseases and infectious diseases
Research Focus:Autoantigen discovery in autoimmune diseasesMass spectrometryPathogenesis of Type 1 DiabetesPost-translational modificationsT cell immunology
Research Focus:Mechanisms of alcoholic liver diseaseMetabolic dysregulation of liver and kidney functionRegulatory nature of sirtuin activity and protein acetylationUtilizing mass spectrometry to investigate proteomics & post-translational modifications
ProfessorPharmaceutical Science Innovation and Commercialization Director
Research Focus:Discovery and Translation of Novel Treatment Approaches to Kidney DiseasesIn Vivo and In Vitro Drug Metabolism and Transport in KidneyNephrotoxicity / BiomarkersPharmacokinetics/Pharmacodynamics/Pharmacogenomics
Colorado Center for Nanomedicine and Nanosafety Co-Director and Co-founderProfessor of Pharmaceutical Sciences, Ophthalmology, and Bioengineering
Research Focus:Nanomedicines for drug delivery gene delivery and imagingNovel drug delivery systems: Nanoparticles microparticles and implants.Novel therapies for diabetic retinopathy macular degeneration and cancers.Ocular respiratory and brain drug discovery delivery and development
ProfessorDirector CU AMC Center for Drug Discovery, Co-Director, Drug Discovery and Development Shared Resource (D3SR)
Research Focus:Drug DesignDrug Mechanism(s) of ActionHTS/HCS Drug DiscoveryIn vitro and In vivo Pharmacokinetics and ToxicologyIn vitro and In vivo PharmacologyMolecular and Cancer BiologyOrganic and Medicinal Chemistry
Professor, Pharmaceutical Sciences Graduate Program Associate Director
Research Focus:2D NMR spectroscopy of antibody therapeuticsBiophysical characterization of protein vaccine stability and aggregationStructure stability and aggregation of protein drug substances and drug productsStructure-function-disease analysis of dystrophin and muscular dystrophy
Assistant ProfessorToxicology Graduate Program Associate Director
Research Focus:Complement-mediated tissue damageExtracellular vesicles and organ-organ crosstalkImmunotherapy and natural immunosuppressionInnate immunity and chronic liver diseases
Associate Dean for Research and Graduate Studies, Professor
Research Focus:Environmental causes of neuronal injuryMitochondrial (dys)function and oxidative stress in epilepsy and neurodegenerationNeuroinflammation and redox signalingRedox-based small molecule therapeutics
Associate ProfessorComputational Chemistry and Biology Core Facility Director
Research Focus:Chemical synthesis of heterocyclic compoundsComputational-based design of novel small moleculesDisrupting drug resistance mechanisms in cancer (DNA damage response)Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)
Research Focus:Metabolomics lipidomics and proteomicsNovel informatics strategies applied to metabolomicsNutrimetabolomicsRole of oxylipins in inflammatory immune and lung diseaseUnderstanding role of host:microbiome metabolism in health and disease
Research Focus:Environmental causes of neurodegeneration e.g. maneb exposureMetabolic consequences of mitochondrial dysfunctionProteostasis and neurodegenerationThiol redox dysregulation in mechanisms of toxicity
Associate ProfessorDirector, Graduate Program in Pharmaceutical Sciences
Research Focus:Genetics of substance use disordersMulti-omics data integrationStatistical methods and bioinformatics techniques for studying complex genetic traitsTranscriptomics and systems genetics