Department Faculty

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Research Focus: Cancer Biology Cancer Pharmacology Warfare vesicants

Research Focus: Antiviral drug pharmacokinetic-pharmacodynamic relationships in humans New assays for drug/metabolite quantification in unique compartments in humans Using drug concentrations to assess adherence to antiviral therapies

Research Focus: Cardiovascular Diseases Clinical Pharmacogenomics Heart Transplantation

Research Focus: Biophysical characterization of therapeutic macromolecules Mechanisms of transcriptional regulation Thermodynamics of protein-protein and protein-DNA interactions

Research Focus: biomarkers drug-drug interactions HIV pediatrics Pharmacokinetics pregnant women tuberculosis

Research Focus: Bladder Cancer Chronic kidney disease of unknown origin (CKDu) Inflammation and immune responses to particulates Mast cells and allergy Nanomedicine and Nanosafety

Research Focus: CAR T and engineered T cell therapies of autoimmune diseases Mechanisms of T cell mediated metal hypersensitivities Mechanisms of T cell recognition of autoantigens in Type 1 diabetes and RA Redox signaling and drug design in the immune diseases and infectious diseases

Research Focus: Autoantigen discovery in autoimmune diseases Mass spectrometry Pathogenesis of Type 1 Diabetes Post-translational modifications T cell immunology

Research Focus: Mechanisms of alcoholic liver disease Metabolic dysregulation of liver and kidney function Regulatory nature of sirtuin activity and protein acetylation Utilizing mass spectrometry to investigate proteomics & post-translational modifications

Research Focus: Biomarkers Discovery and Translation of Novel Treatment Approaches to Kidney Diseases Drug-induced kidney toxicities Genetics of drug efficacy and toxicity In Vivo and In Vitro Drug Metabolism and Transport in Kidney Innovation and entrepreneurship Pharmacokinetics and Pharmacodynamics Preclinical and clinical development of drugs and biologics

Research Focus: Nanomedicines for drug delivery gene delivery and imaging Novel drug delivery systems: Nanoparticles microparticles and implants. Novel therapies for diabetic retinopathy macular degeneration and cancers. Ocular respiratory and brain drug discovery delivery and development

Research Focus: Cancer Pharmacology of Natural Products Public Science Communication Science and Medical Journalism

Research Focus: Drug Design Drug Mechanism(s) of Action HTS/HCS Drug Discovery In vitro and In vivo Pharmacokinetics and Toxicology In vitro and In vivo Pharmacology Molecular and Cancer Biology Organic and Medicinal Chemistry

Research Focus: cytochrome P450 enzymes drug metabolism and disposition enzymology Pharmacokinetics

Research Focus: 2D NMR spectroscopy of antibody therapeutics Biophysical characterization of protein vaccine stability and aggregation Structure stability and aggregation of protein drug substances and drug products Structure-function-disease analysis of dystrophin and muscular dystrophy

Research Focus: Complement-mediated tissue damage Extracellular vesicles and organ-organ crosstalk Immunotherapy and natural immunosuppression Innate immunity and chronic liver diseases

Research Focus: Environmental causes of neuronal injury Mitochondrial (dys)function and oxidative stress in epilepsy and neurodegeneration Neuroinflammation and redox signaling Redox-based small molecule therapeutics

Research Focus: Ecological Roles of Natural Products Host-Microbiome-Environment Interactions Mass Spectrometry Tools for Microbial Systems

Research Focus: Behavioral responses to alcohol Quantitative RNA sequencing Systems genetics

Research Focus: Chemical synthesis of heterocyclic compounds Computational-based design of novel small molecules Disrupting drug resistance mechanisms in cancer (DNA damage response) Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)

Research Focus: Metabolomics lipidomics and proteomics Novel informatics strategies applied to metabolomics Nutrimetabolomics Role of oxylipins in inflammatory immune and lung disease Understanding role of host:microbiome metabolism in health and disease

Research Focus: Environmental causes of neurodegeneration e.g. maneb exposure Metabolic consequences of mitochondrial dysfunction Proteostasis and neurodegeneration Thiol redox dysregulation in mechanisms of toxicity

Research Focus: Genetics of substance use disorders Multi-omics data integration Statistical methods and bioinformatics techniques for studying complex genetic traits Transcriptomics and systems genetics

Research Focus: Immunology and nanoformulations/drug delivery systems Molecular biology immunology and nanotechnology

Research Focus: Cells as carriers of drugs and diagnostics Immune recognition of nanoparticles Isolation of biomarkers and cells from bulk fluids