Center for Translational Pharmacokinetics and Pharmacogenomics

The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.

  • Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
  • Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
  • Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.

Christina Aquilante PharmD

Professor Director of Pharmacogenomics for the Colorado Center for Personalized Medicine

Melanie Joy PharmD, PhD

Professor Director of Innovation and Commercialization, Director of Entrepreneurship Education, SPARK/REACH Program, Director of the Center of Excellence Program for Model Informed Drug Development

Uday Kompella PhD, FARVO, FAAPS

Colorado Center for Nanomedicine and Nanosafety Co-Director and Co-founder Professor of Pharmaceutical Sciences, Ophthalmology, and Bioengineering

Laura Saba PhD

Associate Professor Director

Pharmacokinetics

  • HPLC with UV, Fluorescence, PDA
  • LC-MS (ThermoScientific MSQ)
  • LC-MS-MS (ThermoScientific TSQ Quantum)
  • UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)

Pharmacogenomics

  • DNA isolation
  • Polymerase Chain Reaction
  • Pyrosequencing

Pharmacokinetics

  • NONMEM
  • PDx-POP
  • Pirana
  • PsN
  • Xpose4
  • Phoenix Academic Bundle
  • Phoenix WinNonlin
  • NLME
  • IVIVC
  • Connect
  • Simcyp Simulator
  • Simcyp Animal
  • Boomer

Pharmacogenomics

  • Biotage Primer Design Software
  • PHASE (for haplotype analysis)

Study Design and Statistical Analysis

  • PASS Power and Sample Size Software
  • SPSS Statistical Analysis Software
  • SAS Statistical Analysis Software
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