Center for Pharmaceutical Biotechnology
Biophysical Characterization and Analysis Services for Therapeutic Macromolecules
The Center for Pharmaceutical Biotechnology is focused on the challenges and opportunities associated with training the next generation of pharmaceutical scientists and bioengineers. The center was founded in 1997 by Drs. John Carpenter and Ted Randolph as a collaborative relationship between the PhD programs in pharmaceutical sciences at the Anschutz Medical Campus and chemical engineering at the CU Boulder campus. The Center was home to one of the first NIH training grants in pharmaceutical biotechnology for 16 years. The center specializes in multi-disciplinary scientific education, as well as training in non-scientific disciplines including regulatory affairs, health care policy, technology transfer, finance, and marketing. Faculty associated with the center partner with pharmaceutical biotechnology companies to address contemporary research questions, and the center holds annual Colorado Protein Stability and Aggregation workshops and conferences on issues critical to industry and academic researchers. In addition, the center offers biophysical characterization and analysis services for therapeutic macromolecules such as protein and antibody formulations as described below. For research collaborations, consulting, and fee-for-service biologics characterization, please contact Dr. David Bain (David.Bain@CUAnschutz.edu) or Dr. Krishna Mallela (Krishna.Mallela@CUANschutz.edu).
- Rigorous biophysical analysis, from routine characterization to complex problem solving
- Decades of experience and expertise
- Comprehensive and hypothesis-driven analyses
- Senior professors involved in every step of your project
- State of the art instrumentation, rapid turnaround and insightful reports
- Beckman Optima XLA, XLI, XLF Analytical Ultracentrifuges
- 900 mHz Varian Nuclear Magnetic Resonance Spectrometer with cryoprobe
- 600 mHz Bruker Nuclear Magnetic Resonance Spectrometer
- ZetaSizer Helix: Concomitant Raman Spectroscopy/Dynamic Light Scattering
- Prota 3S Ultrasensitive Infrared Spectrometer
- Chirascan-plus Circular Dichroism Spectrometer with Stop Flow
- PTI QuantaMaster Spectrofluorometers with Stop Flow and Life Time
- Chirascan-plus ACD Auto CD Spectrometer with Robotic System
- Brookhaven Light Scattering System
- MicroCal VP Differential Scanning and Isothermal Titration Calorimeters
- ZetaSizer Nano
- Native-state assembly energetics and hydrodynamics
- Analysis at high macromolecule concentrations
- High viscosity studies
- Opalescence and phase separation
- Thermodynamic stability
- Osmotic second virial coefficients
- Comparability studies
- High-resolution structure and dynamics
