Medicinal chemistry services may be unique to each investigator initiated request. After an initial evaluation and consultation with the investigator, the core will develop a detailed custom synthesis proposal including a scientific literature search, chemical and reagent availability and costs, and a detailed breakdown of costs for each chemical step and analytical identification (i.e. NMR, LC-MS, etc.) based upon target quantity and purity.

Services and Resources

We are here to help validate proof-of-principle target discovery and assist in preclinical

  • Chemical synthesis
  • Assistance in lead compound identification and optimization
  • Structure-activity relationship (SAR) analysis
  • Improvement of chemical properties associated with ADME and/or toxicity issues
  • Literature searching

Michael Wempe PhD

Associate Research Professor Medicinal Chemistry Core Facility Director