Medicinal Chemistry
The Medicinal Chemistry Core Facility can provide a range of services related to chemical services or drug lead development. The Medicinal Chemistry Core Facility is part of the Colorado Clinical and Translational Sciences Institute, CCTSI, an integrated and interdisciplinary statewide academic home for clinical and translational sciences.
Medicinal chemistry services may be unique to each investigator initiated request. After an initial evaluation and consultation with the investigator, the core will develop a detailed custom synthesis proposal including a scientific literature search, chemical and reagent availability and costs, and a detailed breakdown of costs for each chemical step and analytical identification (i.e. NMR, LC-MS, etc.) based upon target quantity and purity.
Services and Resources
We are here to help validate proof-of-principle target discovery and assist in preclinical
- Chemical synthesis
- Assistance in lead compound identification and optimization
- Structure-activity relationship (SAR) analysis
- Improvement of chemical properties associated with ADME and/or toxicity issues
- Literature searching