Pharmacy and Pharmaceutical Sciences Building
12850 East Montview Boulevard
Second Floor Room 2123
Aurora, CO 80045
The theme of my research program is the investigation of how an exposure to a single environmental agent, such as the fungicide maneb, augments the transport and cytotoxic properties of pharmaceuticals, dietary components, and/or chemicals arising from the environment or microbiome. Elucidation of these mechanisms will help to prevent exacerbated toxicity due to alterations in gene expression resulting in enhanced transport of toxicants and xenobiotic interactions. This mechanism may be directly relevant to neurodegenerative diseases like Parkinson’s disease and neurodevelopmental diseases like autism. The aim of the laboratory is to utilize both targeted and systems approaches, such as proteomics, metabolomics and epigenomics, to investigate mechanisms of toxicity.