My laboratory is focused on understanding the role of the quinone reductases in physiological systems and the mechanisms underlying the toxicity of quinones. We then apply that knowledge to a number of different projects in antitumor drug development, environmental toxicology, neurodegeneration and cellular signaling.
Education, Licensure & Certifications
- BSc, University of Aston in Birmingham, England (Pharmacy, Honors)
- PhD, University of Aston in Birmingham, England (Pharmaceutical Chemistry)
- MRPS, Member of the Royal Pharmaceutical Society 1979- ; DABT, Diplomate of the American Board of Toxicology, 1993
Research Interest
- drug development
- pharmacogenomics
- quinone reductases
- Quinones
- selective toxicity of antitumor agents
- targeting of antitumor agents
Publications and Presentations
Redox modulation of NQO1. David Siegel , Donna D. Dehn, Samantha S. Bokatzian, Kevin Quinn, Donald S. Backos, Andrea Di Francesco, Michel Bernier, Nichole Reisdorph, Rafael de Cabo, David Ross. PLoS One, 2018 https://doi.org/10.1371/journal.pone.0190717,
Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. Frontiers in Physiology 8, 595,2017 https://doi.org/10.3389/fphys.2017.00595