Sylvie Kandel PhD

Dr. Sylvie Kandel is a DMPK scientist focusing on the biotransformation of drugs by cytochrome P450 enzymes. After completing her PhD in Biochemistry and Molecular Biology from the University of Strasbourg (France) studying plant cytochrome P450 enzymes, she joined the Ortiz de Montellano lab at UCSF for post-doctoral training. There, she investigated mammalian P450 enzymes using nanodisc technology and collaborated on several projects including the assessment of cytochrome P450 CYP119 ligand binding dynamics using NMR spectroscopy. Through her industrial experiences at Sekisui XenoTech, LLC (Kansas City, KS) and Denali Therapeutics (San Francisco, CA), she applied her drug metabolism knowledge and analytical skills performing metabolite identification and structure elucidation studies of small molecule drug candidates to support drug development. Currently working as a Research Instructor at the University of Colorado, Skaggs School of Pharmacy, she is tackling the intricacy of drug metabolism in neonates as part of the research performed in the Lampe laboratory.