Dr. Sylvie Kandel is a DMPK scientist focusing on the biotransformation of drugs by cytochrome P450 enzymes. After completing her PhD in Biochemistry and Molecular Biology from the University of Strasbourg (France) studying plant cytochrome P450 enzymes, she joined the Ortiz de Montellano lab at UCSF for post-doctoral training. There, she investigated mammalian P450 enzymes using nanodisc technology and collaborated on several projects including the assessment of cytochrome P450 CYP119 ligand binding dynamics using NMR spectroscopy. Through her industrial experiences at Sekisui XenoTech, LLC (Kansas City, KS) and Denali Therapeutics (San Francisco, CA), she applied her drug metabolism knowledge and analytical skills performing metabolite identification and structure elucidation studies of small molecule drug candidates to support drug development. Currently working as a Research Instructor at the University of Colorado, Skaggs School of Pharmacy, she is tackling the intricacy of drug metabolism in neonates as part of the research performed in the Lampe laboratory.
Education, Licensure & Certifications
- Post-doctoral fellowship: Pharmaceutical Chemistry, University of California, San Francisco
- PhD: Biochemistry and Molecular Biology, University of Strasbourg, France
- MS: Biochemistry and Molecular/Cellular Biology, University of Strasbourg, France
- BS: Biochemistry, University of Strasbourg, France
2003-2006, Doctoral Research Fellowship from the French Ministry
- cytochrome P450 enzymes
- drug metabolism and disposition
Publications and Presentations
Kandel, SE, Lampe, JN (2021) Inhibition of CYP3A7 DHEA-S oxidation by Lopinavir and Ritonavir: an alternative mechanism for adrenal impairment in HIV antiretroviral treated neonates. Chem. Res. Toxicol. 34:1150-1160. PMID: 33821626.
Kandel, SE, Han, LW, Mao, Q, Lampe, JN (2017). Digging deeper into CYP3A testosterone metabolism: kinetic, regio- and stereoselectivity differences between CYP3A4/5 and CYP3A7. Drug Metab. Dispo. 45: 1266-1275, PMID: 28986474.
Basudhar, D, Madrona, Y, Kandel, S, Lampe, JN, Nishida, CR, de Montellano, PR. (2015) Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography. J. Biol. Chem. 290:10000-17, PMID: 25670859.
Kandel, SE, Wienkers, LC, Lampe, JN. (2014). Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity. Chem. Res. Toxicol. 9: 1474-1486, PMID: 25133307.