Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and private investigators who wish to incorporate pharmacokinetics and pharmacogenomics into their research programs are invited to contact the Center for opportunities to collaborate with members.
Lauren Vanderlinden MS
Research Instructor
- Skaggs School of Pharmacy and Pharmaceutical Sciences
- Center for Innovative Design & Analysis
Email Address:lauren.vanderlinden@cuanschutz.edu
Primary Phone:303-724-3626
Mailing Address:
- CU Anschutz
Pharmacy and Pharmaceutical Sciences Building
12850 East Montview Boulevard
Aurora, CO 80045
Lauren is a research instructor in the Center for Innovative Design & Analysis at the Colorado School of Public Health. She has over 11 years of experience as a biostatistician conducting research on statistical methods related to the development of precision medicine. She constructs experimental designs, manages data in a proficient manner, executes a variety of statistical analyses, and interprets the results in a biologically meaningful way for the advancement of scientific discovery. She focuses on applying statistical approaches to integrate a variety of high-throughput ‘omic and physiological data. She has extensive experience in constructing, validating, and comparing biological transcriptional networks and has worked in a variety of research models ranging from recombinant inbred animal models to large longitudinal human cohort studies. Statistically determining both the genetic and environmental underpinning of disease is the ultimate goal of her research.
Areas of Expertise
- Omics data analysis
Education, Licensure & Certifications
- MS, Biostatistics, University of Colorado Anschutz Medical Campus
- BA, Chemistry, University of Colorado Boulder
- BA, Mathematics, University of Colorado Boulder
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.