Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Richard Radcliffe PhD
Professor
- Department of Pharmaceutical Sciences
Email Address:richard.radcliffe@cuanschutz.edu
Primary Phone:303-724-3362
Mailing Address:
- CU Anschutz
Pharmacy and Pharmaceutical Sciences Building
12850 East Montview Boulevard
Lab: V20-3460A/C
Office: V20-3124
Aurora, CO 80045
The basic goal of the lab is to map out neuronal pathways that influence behavior related to drug and alcohol abuse with an emphasis on the role of genetics. We use a wide variety of methods including quantitative trait loci (QTL) mapping, gene expression microarray analysis, Next Generation sequencing methods such as RNA-seq, various neurochemical assays, and behavioral testing.
The work is conducted primarily in genetically defined strains of mice and rats. A major focus of the lab is in defining the role of CNS gene expression in genetic differences in acute alcohol sensitivity and tolerance, and how that contributes to pathological alcohol-seeking behavior.
Education, Licensure & Certifications
- BS, Virginia Tech. Blacksburg, Virginia
- PhD, University of Colorado Denver, Denver, Colorado (Pharmaceutical Sciences, Dr. V. Gene Erwin)
- Post-doctoral training, Behavior Genetics, University of Colorado Anschutz Medical Campus (Dr. Richard Deitrich)
- Sabbatical training, Deep Sequencing Computation and Analysis, BioFrontiers Institute (Dr. Robin Dowell)
Affiliations
- Human Medical Genetics and Genomics Program
- Toxicology Program
- Faculty Fellow, Institute for Behavioral Genetics
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.