Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Katerina Kechris PhD
Professor
- Department of Biostatistics & Informatics
- Lifecourse Epidemiology of Adiposity & Diabetes Center; Center for Innovative Design and Analysis
Email Address:katerina.kechris@cuanschutz.edu
Primary Phone:303-724-4363
Mailing Address:
- CU Anschutz
Fitzsimons Building
13001 East 17th Place
Aurora, CO 80045
Dr. Kechris' research focuses on the development and application of statistical methods for analyzing omics data. Dr. Kechris has several focus areas: (1) analyzing transcription factor binding and miRNA data to study the regulation of transcription and post-transcriptional processing, (2) examining the genetic and epigenetic factors controlling gene expression, (3) exploring the metabolome, and (4) integrating multiple omics data. Kechris collaborates with investigators studying alcohol abuse using animal models, chronic obstructive pulmonary disease in the COPDGene genetic epidemiology study, and diabetes and obesity in birth cohorts.
Areas of Expertise
- Biostatistics
- Bioinformatics
- Data science
- Genomics
- Chronic obstructive pulmonary disease
Education, Licensure & Certifications
- PhD, Statistics, University of California Berkeley, 2003
- MA, Statistics, University of California Berkeley, 1999
- BS, Applied Mathematics, University of California Los Angeles, 1997
Awards
- Chancellor’s Teaching Recognition Award, University of Colorado Anschutz Medical Campus, 2020
- Fellow, American Statistical Association, 2019
- Excellence in Faculty Research Award, Colorado School of Public Health, 2017
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.