Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Kristina Brooks PharmD
Assistant Professor
- Department of Pharmaceutical Sciences
Email Address:kristina.brooks@cuanschutz.edu
Primary Phone:303-724-0395
Mailing Address:
- CU Anschutz
Pharmacy and Pharmaceutical Sciences Building
12850 East Montview Boulevard
Lab: V20-4420A(S)
Office: V20-4102
Aurora, CO 80045
My research is focused on clinical pharmacology, drug disposition and drug response in vivo, along with translational approaches to bring an understanding of disease treatment from the bench to the bedside. I have performed research across multiple therapeutic areas, with a primary focus in the treatment and prevention of HIV and related co-infections, notably hepatitis and tuberculosis. The central theme to my work is to inform and optimize safe and effective medication use in persons with HIV, especially infants, children, adolescents and pregnant people.
Education, Licensure & Certifications
- 2017-2018 Fellowship, Antiviral Clinical Pharmacology, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO
- 2015-2017 Fellowship, Clinical Pharmacokinetics, Clinical Pharmacokinetics Research Unit, Clinical Center Pharmacy Department, NIH, Bethesda, MD
- 2011-2015 Doctor of Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI
- 2007-2011 Bachelor of Science in Neuroscience, University of Michigan, Ann Arbor, MI
Awards
- NIH Loan Repayment Program (2019)
- Excellence in Achievement Program, American College of Clinical Pharmacology (2019)
Affiliations
- Department of Pharmaceutical Sciences
- Colorado Antiviral Pharmacology Laboratory
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.