Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Kristina Brooks PharmD, FCP
Assistant Professor
- Department of Pharmaceutical Sciences
Email Address:kristina.brooks@cuanschutz.edu
Primary Phone:303-724-0395
Mailing Address:
- CU Anschutz
Pharmacy and Pharmaceutical Sciences Building
12850 East Montview Boulevard
Mail Stop: C238
Office: V20-4102
Aurora, CO 80045
Dr. Brooks is Co-Director of the Colorado Antiviral Pharmacology (CAVP) Laboratory alongside Dr. Peter Anderson. Her research is focused on the clinical pharmacology of various therapeutics used for HIV, tuberculosis, and hepatitis B/C. She has a particular interest in special populations such as pediatrics, pregnancy, and persons with alcohol and substance use disorder. Dr. Brooks has funding through NIAID, NICHD, and NIAAA to support her ongoing research initiatives.
The CAVP also serves as a pharmacology support laboratory for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) and Advancing Clinical Therapeutics Globally (ACTG) Networks, which involves developing and validating a variety of assays for small molecule drugs under evaluation in these studies. She serves as a pharmacologist for multiple studies through these same networks to support design, oversight, and analysis needs, with some of these efforts leading to regulatory approvals and labeling updates for various antivirals in pediatric and pregnant populations. Dr. Brooks is also a member of the DHHS Perinatal and Pediatric HIV Guidelines Panels and a Fellow in the American College of Clinical Pharmacology.
Areas of Expertise
- Clinical pharmacology
- Pharmacokinetic modeling
- Pediatrics
- Pregnancy
- HIV, tuberculosis, hepatitis B and C
- Pharmacologic measures of adherence
- Alcohol and substance use disorders
- Drug development and repurposing
- Assay development for small-molecule drugs
Education, Licensure & Certifications
- Master of Science in Clinical Science, University of Colorado Anschutz (In Progress)
- Fellowship, Antiviral Clinical Pharmacology, University of Colorado Anschutz, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO (2018)
- Fellowship, Clinical Pharmacokinetics, Clinical Pharmacokinetics Research Unit, Clinical Center Pharmacy Department, NIH, Bethesda, MD (2017)
- Doctor of Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI (2015)
- Bachelor of Science in Neuroscience, University of Michigan, Ann Arbor, MI (2011)
Awards
- NIH Loan Repayment Program (2019)
- Excellence in Achievement Program, American College of Clinical Pharmacology (2019)
Affiliations
- Colorado Antiviral Pharmacology Laboratory
- Department of Pharmaceutical Sciences
- Center for Translational Pharmacokinetics and Pharmacogenomics
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.