Center for Translational Pharmacokinetics and Pharmacogenomics

The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.

  • Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
  • Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
  • Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Christina Aquilante

Christina Aquilante PharmD

Professor Director of Pharmacogenomics for the Colorado Center for Personalized Medicine, Debra Devereaux Endowed Chair in Translational Pharmaceutical Sciences
  • Department of Pharmaceutical Sciences
  • CU/UCHealth

Email Address:christina.aquilante@cuanschutz.edu

Primary Phone:303-724-6126

Mailing Address:
  • CU Anschutz

Lab: V20-4420A

Pharmacy and Pharmaceutical Sciences Building

12850 East Montview Boulevard

Office: V20-4103

Aurora, CO 80045

Dr. Aquilante's patient-oriented clinical research program is aimed at identifying pharmacogenetic determinants of drug disposition, response, and adverse effects in cardiovascular and metabolic diseases. Her research has been funded by the National Institutes of Health, American Heart Association, American College of Clinical Pharmacy, American Association of Colleges of Pharmacy, pharmaceutical industry, and private foundations.

Education, Licensure & Certifications

  • PharmD, University of North Carolina at Chapel Hill 
  • Pharmacy Practice Residency, Shands Hospital at the University of Florida 
  • Post-PharmD Research Fellowship in Cardiovascular Pharmacogenomics, University of Florida College of Pharmacy
  • Certificate in Clinical Science, University of Colorado Clinical Science Graduate Program 

Pharmacokinetics

  • HPLC with UV, Fluorescence, PDA
  • LC-MS (ThermoScientific MSQ)
  • LC-MS-MS (ThermoScientific TSQ Quantum)
  • UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)

Pharmacogenomics

  • DNA isolation
  • Polymerase Chain Reaction
  • Pyrosequencing

Pharmacokinetics

  • NONMEM
  • PDx-POP
  • Pirana
  • PsN
  • Xpose4
  • Phoenix Academic Bundle
  • Phoenix WinNonlin
  • NLME
  • IVIVC
  • Connect
  • Simcyp Simulator
  • Simcyp Animal
  • Boomer

Pharmacogenomics

  • Biotage Primer Design Software
  • PHASE (for haplotype analysis)

Study Design and Statistical Analysis

  • PASS Power and Sample Size Software
  • SPSS Statistical Analysis Software
  • SAS Statistical Analysis Software
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