Center for Translational Pharmacokinetics and Pharmacogenomics

The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.

  • Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
  • Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
  • Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Laura Saba

Laura Saba PhD

Associate Professor Director
  • Department of Pharmaceutical Sciences

Email Address:laura.saba@cuanschutz.edu

Primary Phone:303-724-9697

Mailing Address:
  • CU Anschutz

Pharmacy and Pharmaceutical Sciences Building

12850 East Montview Boulevard

Lab: V20-2210

Office: V20-2124

Aurora, CO 80045

Dr. Laura Saba is an Associate Professor of Bioinformatics in the Department of Pharmaceutical Sciences of the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus. She also has a secondary appointment in the Department of Biostatistics and Informatics at the Colorado School of Public Health, she is part of the Computation Bioscience Program at CU Anschutz,  she is a member of the Training Faculty for the Pharmacology Program within the CU School of Medicine and she is a fellow at the Institute for Behavioral Genetics at CU Boulder.  She received her Bachelor of Science in Chemistry from Colorado School of Mines and her PhD in Biostatistics from the University of Colorado Health Science Center under the supervision of Dr. Diane Fairclough.  She has almost 20 years of experience applying state-of-the-art statistical methodology to health-related studies including genetic, genomic, and proteomic studies of complex traits. Her research focuses on applying systems genetics techniques to high-throughput data to build predictive models. 

Education, Licensure & Certifications

  • BS in Chemistry, Colorado School of Mines, Golden, CO
  • PhD in Biostatistics, University of Colorado Health Science Center (currently Colorado School of Public Health), Denver, CO 

Awards

  • 2022 - Excellence in Pharmaceutical Sciences Doctoral Teaching Award; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus
  • 2020 - Faculty Excellence in Mentoring and Advising; Colorado School of Public Health, University of Colorado Anschutz Medical Campus
  • 2019 - Alumni member - Delta Omega National Honorary Society in Public Health; Colorado School of Public Health, University of Colorado Anschutz Medical Campus
  • 2019 - PhD Alumni Award; Graduate School, University of Colorado Anschutz Medical Campus

Affiliations

  • Fellow - Institute for Behavioral Genetics; University of Colorado | Boulder
  • Core Faculty - Computational Bioscience Program; University of Colorado | Anschutz Medical Campus
  • Training Faculty - Pharmacology PhD Program; University of Colorado | Anschutz Medical Campus
  • Secondary Appointment - Department of Biostatistics and Informatics; Colorado School of Public Health

Pharmacokinetics

  • HPLC with UV, Fluorescence, PDA
  • LC-MS (ThermoScientific MSQ)
  • LC-MS-MS (ThermoScientific TSQ Quantum)
  • UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)

Pharmacogenomics

  • DNA isolation
  • Polymerase Chain Reaction
  • Pyrosequencing

Pharmacokinetics

  • NONMEM
  • PDx-POP
  • Pirana
  • PsN
  • Xpose4
  • Phoenix Academic Bundle
  • Phoenix WinNonlin
  • NLME
  • IVIVC
  • Connect
  • Simcyp Simulator
  • Simcyp Animal
  • Boomer

Pharmacogenomics

  • Biotage Primer Design Software
  • PHASE (for haplotype analysis)

Study Design and Statistical Analysis

  • PASS Power and Sample Size Software
  • SPSS Statistical Analysis Software
  • SAS Statistical Analysis Software
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