Center for Translational Pharmacokinetics and Pharmacogenomics
The center is a collaborative group of pharmacokinetics and pharmacogenomics experts with the scientific and technical expertise, knowledge, and physical resources to conduct high-level translational research in these fields.
- Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
- Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
- Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.
Academic and external investigators working in preclinical and clinical development of drugs and biologics, or conducting independent research, can contact Center members directly for opportunities to collaborate and develop appropriate strategies for integration of pharmacokinetics, pharmacodynamics and pharmacogenetics.
Paula Hoffman PhD
Professor
- Pharmacology (SOM)
Email Address:paula.hoffman@cuanschutz.edu
Primary Phone:303-724-3628
Mailing Address:
- CU Anschutz
Research I North
12800 East 19th Avenue
Aurora, CO 80045
Pharmacokinetics
- HPLC with UV, Fluorescence, PDA
- LC-MS (ThermoScientific MSQ)
- LC-MS-MS (ThermoScientific TSQ Quantum)
- UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)
Pharmacogenomics
- DNA isolation
- Polymerase Chain Reaction
- Pyrosequencing
Pharmacokinetics
- NONMEM
- PDx-POP
- Pirana
- PsN
- Xpose4
- Phoenix Academic Bundle
- Phoenix WinNonlin
- NLME
- IVIVC
- Connect
- Simcyp Simulator
- Simcyp Animal
- Boomer
Pharmacogenomics
- Biotage Primer Design Software
- PHASE (for haplotype analysis)
Study Design and Statistical Analysis
- PASS Power and Sample Size Software
- SPSS Statistical Analysis Software
- SAS Statistical Analysis Software
Designated as a Center of Excellence for Model-informed Drug Development (MDD)
Our program is designated as a Center of Excellence by Certara, a global leader in biosimulation. We are one of only five pharmacy schools in the nation to receive this designation which allows our students to use Certara’s Phoenix software suite as part of their analyses and method development.