• Pharmacokinetics: the study of the time course of absorption, distribution, metabolism, and excretion (i.e., disposition) of drugs in the body.
  • Pharmacodynamics: the study of the relationship between drug concentrations and drug response in the body.
  • Pharmacogenomics: the study of how genetic variation influences interindividual variability in drug disposition and response.

Academic and private investigators who wish to incorporate pharmacokinetics and pharmacogenomics into their research programs are invited to contact the Center for opportunities to collaborate with members.

Paula Hoffman PhD

Professor
  • Pharmacology (SOM)

Email Address:paula.hoffman@cuanschutz.edu

Primary Phone:303-724-3628

View Research Profile

Mailing Address:
  • CU Anschutz

Research I North

12800 East 19th Avenue

Aurora, CO 80045

Pharmacokinetics

  • HPLC with UV, Fluorescence, PDA
  • LC-MS (ThermoScientific MSQ)
  • LC-MS-MS (ThermoScientific TSQ Quantum)
  • UPLC-MS-MS (ThermoScientific Accela-TSQ Vantage)

Pharmacogenomics

  • DNA isolation
  • Polymerase Chain Reaction
  • Pyrosequencing

Pharmacokinetics

  • NONMEM
  • PDx-POP
  • Pirana
  • PsN
  • Xpose4
  • Phoenix Academic Bundle
  • Phoenix WinNonlin
  • NLME
  • IVIVC
  • Connect
  • Simcyp Simulator
  • Simcyp Animal
  • Boomer

Pharmacogenomics

  • Biotage Primer Design Software
  • PHASE (for haplotype analysis)

Study Design and Statistical Analysis

  • PASS Power and Sample Size Software
  • SPSS Statistical Analysis Software
  • SAS Statistical Analysis Software