Daniel LaBarbera

Daniel Labarbera PhD

Associate Professor, HTS Drug Discovery and Chemical Biology Core Director
Pharmaceutical Sciences
  • Skaggs School of Pharmacy and Pharmaceutical Sciences

Recent Publications


Director, HTS/HCS and chemical biology core facility

Office Location:

Pharmacy and Pharmaceutical Sciences Building (V20)
Second Floor Room 2101

Research Interests:

  • Organic and Medicinal Chemistry
  • Molecular and Cancer Biology
  • HTS/HCS Drug Discovery
  • Drug Design
  • Drug Mechanism(s) of Action
  • In vitro and In vivo Pharmacology
  • In vitro and In vivo Pharmacokinetics and Toxicology

Representative publications:

LaBarbera, D.V.; Reid, B.G.; Yoo, B.H., The multicellular tumor spheroid model for high-throughput cancer drug discovery. Expert Opin Drug Dis 2012, 0, 1-12.

Puppala, M.; Ponder, J.; Suryanarayana, P.; Reddy, G.B.; Petrash, J.M.; LaBarbera, D.V., The Isolation and Characterization of β-Glucogallin as a Novel Aldose Reductase Inhibitor from Emblica officinalis. PLoS One 2012, 7, e31399.

Li, L.; Chang, K.C.; Zhou, Y.; Shieh, B.; Ponder, J.; Abraham, A.D.; Ali, H.; Snow, A.; Petrash, J.M.; LaBarbera, D.V., Design of an amide N-glycoside derivative of beta-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem 2014, 57, 71-77.

Reid, B.G.; Jerjian, T.; Patel, P.; Zhou, Q.; Yoo, B.H.; Kabos, P.; Sartorius, C.A.; Labarbera, D.V., Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery. Curr Chem Genomics Transl Med 2014, 8, 27-35.

Li, L.; Zhou, Q.; Voss, T.C.; Quick, K.L.; LaBarbera, D.V., High-throughput imaging: Focusing in on drug discovery in 3D. Methods 2016, 96, 97-102.

Zhou, Q.; Abraham, A.D.; Li, L.; Babalmorad, A.; Bagby, S.; Arcaroli, J.J.; Hansen, R.J.; Valeriote, F.A.; Gustafson, D.L.; Schaack, J.; Messersmith, W.A.; LaBarbera, D.V., Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer. Oncogene 2016, 35, 4990-4999.

Bashyal, B.; Li, L.; Bains, T.; Debnath, A.; LaBarbera, D.V., Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Negl Trop Dis 2017, 11, e0005832.

Li, L.; LaBarbera, D.V., 2.16 - 3D High-Content Screening of Organoids for Drug Discovery. In Comprehensive Medicinal Chemistry III, Rotella, D.; Ward, S.E., Eds. Elsevier: Oxford, 2017; pp 388-415.