Research in the Brown lab is focused on immune responses to particles including nanoparticles, air pollution, silica and coal dust. In particular, our research group investigates the role of innate immune cells, including mast cells and macrophages, in response to particles. In addition, we are interested in understanding the toxicity of engineered nanomaterials as well as their use in drug delivery and treatment of cancer.
Education, Licensure & Certifications
- BS, Colorado State University, Fort Collins, CO
- PhD, University of Montana, Center for Environmental Health Sciences, Skaggs School of Pharmacy, Missoula, MT
- Postdoctoral – Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
- Bladder Cancer
- Chronic kidney disease of unknown origin (CKDu)
- Inflammation and immune responses to particulates
- Mast cells and allergy
- Nanomedicine and Nanosafety
Katwa P, Wang X, Urankar RN, Podila, R, Hilderbrand SC, Fick RB, Rao AM, Ke PK, Wingard CJ, Brown JM. A Carbon Nanotube Toxicity Paradigm Driven by Mast Cells and the IL-33/ST2 Axis. Small. 2012.
Johnson M, Alsaleh N, Mendoza RP, Persaud I, Bauer AK, Saba L, Brown JM. Genomic and Transcriptomic Comparison of Allergen and Silver Nanoparticle-Induced Mast Cell Degranulation Reveals Novel Non-Immunoglobulin E Mediated Mechanisms. PLOS One. 2018.