Research in the Brown lab is focused on immune responses to particles including nanoparticles, air pollution, silica and coal dust. In particular, our research group investigates the role of innate immune cells, including mast cells and macrophages, in response to particles. In addition, we are interested in understanding the toxicity of engineered nanomaterials as well as their use in drug delivery and treatment of cancer.
Education, Licensure & Certifications
- BS, Colorado State University, Fort Collins, CO
- PhD, University of Montana, Center for Environmental Health Sciences, Skaggs School of Pharmacy, Missoula, MT
- Postdoctoral – Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD
Research Interest
- Bladder Cancer
- Chronic kidney disease of unknown origin (CKDu)
- Inflammation and immune responses to particulates
- Mast cells and allergy
- Nanomedicine and Nanosafety
Research
Keegan L. Rogers, Carlos A. Roncal-Jimenez, Ricardo Leiva, Arthur Stem, Julia Wijkstrom, Lissbeth Serpas, Marvin A. Gonzalez-Quiroz, Fumihiko Sasai, Annika Wernerson, Joshua Schaeffer, Jacob Fox, Matthew Ray, Anip Bansal, Manuel Urra, Jaime Butler-Dawson, Scott Lucia, Lee Newman, Jason Glaser, Richard J. Johnson, Jared M. Brown. Silica Nanoparticles and Mesoamerican Nephrophathy: A Case Series. 2023. American Journal of Kidney Diseases.
Angela Cruz-Hernandez, Ryan P. Mendoza, Kathleen Nguyen, Anna Harder, Christopher Evans, Alison K. Bauer, Neera Tewari-Singh, Jared M. Brown. Mast Cells Promote Nitrogen Mustard Mediated Toxicity in the Lung Associated with Proinflammatory Cytokine and Bioactive Lipid Mediator Production. 2021. Toxicological Sciences.
Ryan P. Mendoza, Colin C. Anderson, Dylan H. Fudge, James R. Roede, Jared M. Brown. Metabolic Consequences of IgE and non-IgE Mediated Mast Cell Degranulation. 2021. Journal of Immunology.