Dr. Orth is an Assistant Professor in the Department of Clinical Pharmacy, where his teaching, clinical practice, and research activities focus on optimizing the medical care of pediatric patients. Within the curriculum, Dr. Orth teaches in the Clinical Pharmacokinetics, Pharmacotherapy, and Capstone courses across all Doctor of Pharmacy programs. He is also the course director for two Pediatric Pharmacotherapy electives. In addition to his teaching roles, Dr. Orth practices as an embedded pharmacist within the Special Care Clinic at Children's Hospital Colorado, a patient-centered medical home for ~6,000 children with medical complexity. Within this role, Dr. Orth works collaboratively with providers and multidisciplinary staff to provide comprehensive pharmacotherapy recommendations, patient/caregiver education, and other medication-related support to children with medical complexity and their families. His current clinical research focuses on optimization of medication therapy management practices in children with polypharmacy, and expansion of pharmacy services to children with medical complexity. Additional scholarship interests include pediatric critical care and emergency preparedness, pharmacoepidemiology, medication safety for children with neurocognitive impairment, and pediatric practice management.
Education, Licensure & Certifications
- Doctor of Pharmacy, University of Kentucky College of Pharmacy (2011-2015)
- Pharmacy Practice Residency, UF Health Shands Hospital (2015-2016)
- Pediatric Pharmacy Specialty Residency, UF Health Shands Children’s Hospital (2016-2017)
Awards
- Outstanding Preceptor of the Year, University of Colorado Skaggs School of Pharmacy (2023)
- Top 25 Article of the Year, American Journal of Health-System Pharmacy (2022)
- Distinguished Young Pharmacist Award, Colorado Pharmacists Society (2024)
Affiliations
- Department of Pediatrics, University of Colorado School of Medicine
- Department of Pharmacy, Children's Hospital Colorado
Courses
- Pediatric Pharmacotherapy
- Pharmacotherapy IV
- Clinical Pharmacokinetics
- Clinical Capstone
- Dermatology & HEENT II (School of Medicine CHA/PA program)
Research
- Polypharmacy
- Pediatric Medication Therapy Management
- Pediatric Pharmacoepidemiology
- Medication Safety in Children with Neurocognitive Impairment
Publications and Presentations
- Orth LE, Feudtner C, Kempe A, et al. A coordinated approach for managing polypharmacy among children with medical complexity: rationale and design of the Pediatric Medication Therapy Management (pMTM) randomized controlled trial. BMC Health Services Research. 2023;23:414.
- Feinstein JA, Orth LE. Making polypharmacy safer for children with medical complexity. Journal of Pediatrics. 2023;254:4-10.
- Marquez C, Thompson R, Feinstein, JA, Orth LE. Identifying opportunities for pediatric medication therapy management in children with medical complexity. Journal of the American Pharmacists Association. 2022;62:1587-95.e3.
- Feinstein JA, Friedman H, Orth LE, et al. Complexity of medication regimens for children with neurological impairment. JAMA Network Open. 2021;4:e2122818.
- Feinstein JA, Feudtner C, Kempe A, Orth LE. Anticholinergic medications and parent-reported
anticholinergic symptoms in neurologically impaired children. Journal of Pain and Symptom Management.
2023 Feb;65(2):e109-14. - Elias ER, Orth LE, Xu L, Jones SM, Rizzo WB. Cholic acid increases serum cholesterol in Smith-LemliOpitz syndrome: a pilot study. Molecular Genetics and Metabolism Reports. 2023 Nov 28;38(1):101030.
- Orth LE, Kelly BK, Lagasse CL, et al. Safety and effectiveness of albuterol solutions with and without benzalkonium chloride when administered by continuous nebulization. American Journal of Health-Systems Pharmacy. 2018;75:1791-7.
- Orth LE, O’Mara KL. Impact of early versus late diuretic exposure on metabolic bone disease and growth in premature neonates. Journal of Pediatric Pharmacology and Therapeutics. 2018;23:26-33.