The long-term goal of our research is to elucidate biochemical mechanisms of cellular dysfunction resulting from altered protein post-translational modifications (PTMs). Specifically, our lab focuses on the downstream effects of protein carbonylation due to lipid peroxidation and protein acylation due to altered liver metabolism.
Education, Licensure & Certifications
- BS, La Sierra University, Riverside, CA (Biochemistry)
- PhD, Loma Linda University, Loma Linda, CA (Biochemistry)
- Postdoctoral Fellow, University of Colorado
- Faculty Member – School of Medicine, Division of Cardiology
- Board Member - Colorado Biological Mass Spectrometry Society
- Mechanisms of alcoholic liver disease
- Metabolic dysregulation of liver and kidney function
- Regulatory nature of sirtuin activity and protein acetylation
- Utilizing mass spectrometry to investigate proteomics & post-translational modifications
Publications and Presentations
Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS. Quantifying competition among mitochondrial protein acylation events induced by ethanol metabolism. J Proteome Res. 2019 Jan 15. PMID: 30644754.
Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714.
Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015;6:33-40.