HTS/HCS Drug Discovery and Hit-to-Lead Drug Development

This site is specific for researchers interested in utilizing the D3SR Arm, which specializes in HTS/HCS probe and drug discovery using cellular and biochemical systems. We also specialize in three-dimensional (3D) HTS/HCS of complex cell-based models, organoids and tumor organoids (cell line or patient derived). This facility is newly renovated and features a new state-of-the-art custom robotic automation platform (the Explorer G3) that integrates new HTS/HCS instrumentation and equipment from PerkinElmer, and other leading vendors.

Other Equipment Utilized for Assay Development Not Integrated with The Explorer G3

  • Generation 1 Opera Phenix HCS System
  • Janus Automated Liquid Handling Platform (96- channel MDT heads and 8-channel Varispan)
  • Envision multi-mode plate reader (Filter based)
  • Columbus Signals Image Artist Server
  • 4-foot Bio-Safety Cabinet (safety level II)

Compound Libraries

Kinase Inhibitor Library (SelleckChem): 875 compounds including clinically relevant or FDA approved kinase inhibitors.

Spectrum Collection (Discovery Systems): 2,320 compounds approved drugs (50%), diverse natural products (30%), and other bioactive compounds (20%).

Custom Drug-Like Diversity Sets (120,000 compounds): These libraries are intended for discovering drug-like molecules that can be translated into novel intellectual property. Inherent to these libraries are derivatives of each chemical scaffold, which can yield SAR (structure-activity relationship) that can guide downstream medicinal chemistry efforts. These libraries have been filtered to remove undesirable compounds (PAINS)

  • Diversity Library 1 has 20,000 compounds (Life Chemicals).
  • Diversity Library 2 has 50,000 compounds (ChemBridge)
  • Diversity Library 3 has 50,000 CNS specific compounds (ChemBridge)

Other Drug Discovery Core Facilities

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Computational Chemistry and Biology Core Facility

The Computational Chemistry and Biology (CCB) Core Facility provides a wide array of advanced tools and services for computational modeling simulations chemical and biological systems. 

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Medicinal Chemistry Core Facility

The Medicinal Chemistry Core Facility can provide a range of services related to chemical synthesis and lead drug development. 

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Mass Spectrometry (MS) Core Facility

The MS core facility utilizes advanced mass spectrometry instrumentation and techniques to assist researchers with their proteomic, metabolomics, and small molecule research.