This site is specific for researchers interested in utilizing the D3SR Arm, which specializes in HTS/HCS probe and drug discovery using cellular and biochemical systems. We also specialize in three-dimensional (3D) HTS/HCS of complex cell-based models, organoids and tumor organoids (cell line or patient derived). This facility is newly renovated and features a new state-of-the-art custom robotic automation platform (the Explorer G3) that integrates new HTS/HCS instrumentation and equipment from PerkinElmer, and other leading vendors.
Other Equipment Utilized for Assay Development Not Integrated with The Explorer G3
The Explorer G3 Work station (PerkinElmer) is a custom designed automation platform that is fully enclosed, maintaining a clean sterile environment through a HEPA filtration system. The Explorer G3 has three levels, the main deck, and a middle and lower deck used to house instrumentation and equipment. The Explorer G3 has a track system robotic arm that integrates equipment on both the main and middle decks.
Kinase Inhibitor Library (SelleckChem): 875 compounds including clinically relevant or FDA approved kinase inhibitors.
Spectrum Collection (Discovery Systems): 2,320 compounds approved drugs (50%), diverse natural products (30%), and other bioactive compounds (20%).
Custom Drug-Like Diversity Sets (120,000 compounds): These libraries are intended for discovering drug-like molecules that can be translated into novel intellectual property. Inherent to these libraries are derivatives of each chemical scaffold, which can yield SAR (structure-activity relationship) that can guide downstream medicinal chemistry efforts. These libraries have been filtered to remove undesirable compounds (PAINS)
The Computational Chemistry and Biology (CCB) Core Facility provides a wide array of advanced tools and services for computational modeling simulations chemical and biological systems.
The Medicinal Chemistry Core Facility can provide a range of services related to chemical synthesis and lead drug development.