Medicinal Chemistry Core Facility
Medicinal Chemistry Core Facility
Mission
Our mission is to provide comprehensive support for medicinal chemistry, encompassing both small molecules and biologics, to advance innovative molecular tools and lead drug therapies toward clinical translation of investigational new drugs for clinical development.
Overview
The Medicinal Chemistry Core Facility is open to working with researchers in both academia and industry to identify biologically active small molecules to advance their understanding of disease models and the underlying molecular mechanisms. We work closely with the HTS/HCS and Pharmacology core facilities to select the most promising hits from initial screens, execute their multistep organic synthesis and development into lead molecules for further structure-activity-relationship (SAR)-guided lead optimization.
Services
- Hit selection and development into drug leads
- Lead optimization and SAR development
- Small molecules multistep-organic synthesis from milligram to multigram scale
- Improve drug-like properties (physicochemical properties)
- Lead drug analog design and synthesis tailored to your research needs
- Chemical probes design and synthesis for target identification and validation
- Structure-based and ligand-based drug design approaches
- Scale-up synthesis and purification of validated lead molecules
- Compound purity analysis and structural determination using modern techniques
- Thermodynamic solubility determination
- Expert consultation to guide your small molecule drug discovery projects and grant applications
Contact Us
Professor and Director, the CU Anschutz Center for Drug Discovery
Email: daniel.labarbera@cuanschutz.edu
Phone: 303-724-4116
Research Associate and Medicinal Chemistry Core Manager
Email: paul.awolade@cuanschutz.edu
Phone: 303-724-9278
To learn more visit the D3SR core facility links below and navigate to the D3SR iLabs website to request for consultation or drug discovery and development services.