2024 Colorado Protein Stability Conference – 30th Anniversary

Protein stability is important in numerous disciplines, ranging from fundamental and applied protein biophysics to basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all of the relevant areas can join together to discuss the critical issues in the field in a more relaxed setting. Since 1994, Colorado Protein Stability Conferences have provided unique opportunities for this exchange of information. The topics that will be covered during 2024 Conference include: protein structure, thermodynamic stability, folding, and dynamics; stability of AAV vectors; amyloidosis and protein aggregation; engineering protein therapeutics; protein-excipient interactions; characterization of protein particles and new advances in processing of therapeutic proteins.

The scientific sessions will consist of plenary lectures by leading researchers from both academia and pharmaceutical industry. In addition, contributed papers will be presented during a half-day poster session with ample opportunities for young investigators to network and discuss their research. To foster exchange of information, attendance will be limited to the first 200 registrants.

The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.

Sponsored By


Applied Photophysics
clear_solutions_laboratories_cover
Fluid-Imaging-jpeg
jasco
Reneron

 



John Carpenter PhD

Emeritus Professor, University of Colorado Center for Pharmaceutical Biotechnology

Email Address:john.carpenter@cuanschutz.edu
Primary Phone:303-724-6110


Krishna Mallela, PhD

Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus

Email: krishna.mallela@cuanschutz.edu
Phone: 303-724-3576

 


ted_randolph

Ted Randolph, PhD

Gillespie Professor, Chemical and Biological Engineering, University of Colorado Boulder

Email: theodore.randolph@colorado.edu
Phone
: 303-492-4776

Conference Schedule

Monday, August 5

3:00 pm

7:00 pm

Registration Opens 

Opening Reception 
Copper Top II/III

Tuesday, August 6

7:00 am
Breakfast
Copper Top II/III
8:00 am

Welcoming Comments
Colorado Ballroom

Protein Structure, Stability and Dynamics - I 
Colorado Ballroom

8:05 am

Ken Dill, Stony Brook University 
Modeling and modulating protein-protein interactions

8:40 am
Susan Marqusee, University of California Berkeley

9:15 am


9:50 am

Doug Barrick, John Hopkins University 
Using conservation and covariance patterns to design stability and function in proteins 

Pete Tessier, University of Michigan
Predicting antibody developability using machine learning 

10:25 am
Coffee Break


Protein Structure, Stability and Dynamics - II
Colorado Ballroom

10:45 am
Patricia Clark, University of Notre Dame
Off to a great start: Impact of early intermediates on protein folding success

11:20 am


11:55 am

George Makhatadze, Rensselaer Polytechnic Institute 
Effects of High Hydrostatic Pressure on the Stability and Function of Biomacromolecules

Gilad Haran, Weizmann Institute of Science
How a protein disaggregation machine works: lessons from single-molecule FRET
12:30 pm
Introduction from Lunch Sponsor 

12:40 pm
Lunch
Copper Top II/III


Stability of Viral Vectors
Colorado Ballroom

2:00 pm
Susumu Uchiyama, Osaka University
Analytical development and quality control of virus vectors

2:35 pm
Jared Bee, RegenXBio Inc.
Development of AAV Gene Therapies 
3:10 pm
Sambit Kar, Spark Therapeutics 

3:45 pm
Coffee Break

 

Amyloidosis and Protein Aggregation
Colorado Ballroom

4:05 pm
Birgit Strodel, Research Center Julich
Structural Odyssey of Amyloid-β: Navigating the Conformational Landscape in Alzheimer's Pathogenesis  
4:40 pm

Reza Nejad Nik, University of Iowa
Assessment of self-association of monoclonal antibody molecules by analysis of the protein layer detected at the proximity of a solid surface 

5:15 pm
Chris Roberts, University of Delaware 
Complex pathways for aggregation of multi-valent proteins  

5:50 pm

6:00 pm

Introduction to Reception Sponsor Halo Labs

Colorado Beer Tasting Reception
Sponsored by Halo Labs
Copper Top II/III


Wednesday, August 7

7:30 am
Breakfast
Copper Top II/III
9:00 am

Poster Session
Colorado Ballroom
9:00 am - 11:00 am Even-numbered posters

11:00am - 1:00pm Odd-numbered posters 

1:00 pm
Lunch
Copper Top II/III

Thursday, August 8

7:00 am
Breakfast
Copper Top II/III


Protein subunit vaccines
Colorado Ballroom

8:00 am
Christopher B. Fox, Senior Vice President, Formulations
Access to Advanced Health Institute
Advanced Development of Dried Presentations of the ID93 + GLA-SE Tuberculosis Vaccine Candidate

8:35 am
Johannes P.M. Langedijk, Janssen Vaccines
Role of prefusion stabilized glycoproteins in vaccine design

9:10 am
Ted Randolph, University of Colorado Boulder
Atomic Layer Deposition for Stabilization and Delivery of Virus-Based Vaccines

9:45 am
Coffee Break


Protein – Excipient Interactions
Colorado Ballroom

10:20 am

Raj Suryanarayanan, University of Minnesota
Implications of excipient phase behavior on protein stability

10:55 am
Douglas Kamen, Regeneron
Evaluation of the in-use stability of monoclonal antibody IV admixtures prepared from drug products containing polysorbate 20 degraded by host cell lipases

11:30 am
Atanas Koulov, Clear Solutions
Surfactants in biopharmaceutical development: stability challenges and mitigation strategies

12:05 pm
Lunch
Copper Top II/III


Particles in Protein Drug Products
Colorado Ballroom

1:30 pm
Ewa Marszal, FDA
A perspective on the history of the pharmacopeial limits for subvisible particulate matter

2:05 pm
Steven Hudson, NIST
2:40 pm
Yongchao Su, Merck
Protein Aggregation in High-Concentration Biologics: Uncovering the Role of Device-Related Stress Factors

3:15 pm
Coffee Break


Processing and Delivery of Biologics
Colorado Ballroom

3:45 pm
Satish Singh, Moderna
mRNA-LNPs. A platform approach to formulation and process development

4:20 pm
Twinkle Christian, Amgen 
Patient Centric Drug Development

4:55 pm

 

 

5:30 pm

Wolfgang Friess, Ludwig-Maximilians University
Cool & Highly Concentrated – Understanding Protein Stability And Interactions In The Frozen State As Basis For Sustainable Frozen Storage

 

Student Poster Awards & Closing Comments

6:00 pm
Closing Reception
Copper Top II/III

Evening opening reception

There will be an opening reception with buffet dinner and beverages at 7 pm on Monday, August 5.

Closing Reception

There will be a closing reception with buffet dinner and beverages at 6 pm on Thursday, August 8.

Registration

The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.

Early Registration Fees (before July 5)
Industry Registration Fee (Individual)$1850
Industry Registration Fee (Groups of 5 or more)$1450
Academic Registration Fee$900
Government Rate$600
Student/Postdoc Rate$400
Standard Registration Fees (after July 5)
Industry Registration Fee$2150
Industry Registration Fee (Groups of 5 or more)$1750
Academic Registration Fee$1200
Government Rate$750
Student/Postdoc Rate$650

Register Here

 

 

Cancellation Policy

Only requests for cancellation received prior to July 5th, 2024 will receive a refund, minus a $100 processing fee. If cancellation is not received by July 5th, 2024, the registration fee will be forfeited.

Contact for further information

For sponsorship opportunities and general information, please contact:

John Carpenter
303-724-6110
John.Carpenter@cuanschutz.edu

Krishna Mallela
303-724-3576
Krishna.Mallela@cuanschutz.edu

Ted Randolph

303-492-4776
theodore.randolph@colorado.edu

More information

Ground Transportation from Denver International Airport

There are two main shuttle services available from the Denver airport to the hotel in Breckenridge. And, of course, car rentals are also available at the airport.

Colorado Mountain Express
http://www.coloradomountainexpress.com
Phone: 1-800-525-6363 Reservations
Phone: 1-970-754-7433 Local

Summit Express
http://www.summitexpress.com/
Phone: 1-855-MTN-VANS | 970-668-6000

Conference Location & Hotel Room Reservation

 

Beaver Run Resort and Conference Center
620 Village Road Breckenridge, Colorado 80424-2115
Phone: (970) 453-6000
Phone: (800) 525-2253
Registration on the Resort website using the link for Conference special rates
Call In Reservations: Please call the Resort's Reservations Department any time at 800-525-2253 and ask for the “2024 Colorado Protein Stability Conference” group rates.

Also, please note that the Conference room block will be held until July 5, 2024. After that date, the group rates will still be honored, if rooms are available. However, because the Resort often sells out in the summer, please make your reservations early.

 

Special Conference Room Rates:

RoomRate
Hotel$186.00
Studio$186.00
Breckenridge Studio$191.00
Colorado Suite$204.00
Summit Suite$216.00
One Bedroom Suite$216.00
One Bedroom Suite Bldg. 4$216.00
Two Bedroom Suite$289.00
Two Bedroom Suite Bldg. 4$289.00
Corporate Suite $454.00

Room Descriptions:

  • Hotel Room features two beds, full bath, mini-fridge, microwave, small sitting area
  • Studio features one queen bed, sleeper sofa, efficiency-kitchen, living/dining area
  • Breckenridge Studio features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath
  • Colorado Suite features queen bed, sleeper sofa, efficiency-kitchen, living/dining area, fireplace, private balcony
  • Summit Suite features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath, fireplace, private balcony
  • One Bedroom Suite features queen bed, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony
  • One Bedroom Suite Building 4 features queen bed, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony
  • Two Bedroom Suite features three queen beds, sleeper sofa, two bathrooms, full kitchen, living/dining area, fireplace, private balcony
  • Two Bedroom Suite Building 4 features two queen beds, sleeper sofa, two bathrooms, full kitchen, living/dining area, fireplace, private balcony
  • Corporate Suite features one king bed, one queen bed, additional alcove bedding, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony

Room rates do not include 19.01% Tax and Resort Fee. There is a nightly parking fee of $10.00 per vehicle, per night. There is a limit of one vehicle per bedroom.

 

The Resort shall have no responsibility or liability whatsoever for any descriptions or representations made to Group members regarding the Resort property, unless such descriptions or representations are approved in advance by the Resort.

Poster Session

There will be a poster session for contributed papers on the morning of Wednesday, August 7. This session will allow for further discussions of the critical issues.

Abstract Submission

Abstracts should be prepared on a single page with one-inch margins, and should include the abstract title, list of authors, affiliations, contact email of the presenting author, and the abstract text. Black and white figures can be included, but the entire abstract should be within the one-page limit. Abstracts will be reproduced as received for the proceedings of the Conference. Abstracts should be submitted online no later than July 5th, 2024.

Student Poster Competition

The Center for Pharmaceutical Biotechnology and the Conference Sponsors are proud to sponsor this competition to promote excellence in student research. The cash prizes are: $1000 for the winner, $500 for first runner-up and $250 for second runner-up.

When submitting abstracts online, students should indicate that they wish to enter the competition.

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