2024 Colorado Protein Stability Conference – 30th Anniversary
Protein stability is important in numerous disciplines, ranging from fundamental and applied protein biophysics to basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all of the relevant areas can join together to discuss the critical issues in the field in a more relaxed setting. Since 1994, Colorado Protein Stability Conferences have provided unique opportunities for this exchange of information. The topics that will be covered during 2024 Conference include: protein structure, thermodynamic stability, folding, and dynamics; stability of AAV vectors; amyloidosis and protein aggregation; engineering protein therapeutics; protein-excipient interactions; characterization of protein particles and new advances in processing of therapeutic proteins.
The scientific sessions will consist of plenary lectures by leading researchers from both academia and pharmaceutical industry. In addition, contributed papers will be presented during a half-day poster session with ample opportunities for young investigators to network and discuss their research. To foster exchange of information, attendance will be limited to the first 200 registrants.
The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.
Sponsored By
John Carpenter PhD
Emeritus Professor, University of Colorado Center for Pharmaceutical Biotechnology
Email Address:john.carpenter@cuanschutz.edu
Primary Phone:303-724-6110
Krishna Mallela, PhD
Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus
Email: krishna.mallela@cuanschutz.edu
Phone: 303-724-3576
Ted Randolph, PhD
Gillespie Professor, Chemical and Biological Engineering, University of Colorado Boulder
Email: theodore.randolph@colorado.edu
Phone: 303-492-4776
Conference Schedule
Monday, August 5
| 3:00 pm | Registration Opens |
| 7:00 pm | Opening Reception Copper Top II/III |
Tuesday, August 6
| 7:00 am | Breakfast Copper Top II/III |
| 8:00 am | Welcoming Comments Colorado Ballroom |
| Protein Structure, Stability, and Dynamics - I Session Chair: Blake Hill, University of Colorado Colorado Ballroom | |
| 8:05 am | Ken Dill, Stony Brook University (S1) Next-gen modeling for protein association and solvation |
| 8:40 am | Susan Marqusee, University of California Berkeley (S2) Labeling Rare and Transient Conformations on the Landscape |
| 9:15 am | Doug Barrick, Johns Hopkins University (S3) Using conservation and covariance patterns to design stability and function in proteins |
| 9:50 am | Coffee Break |
| Protein Structure, Stability, and Dynamics - II Session Chair: David Bain, University of Colorado Colorado Ballroom | |
| 10:20 am | Pete Tessier, University of Michigan (S4) Predicting antibody developability using machine learning |
| 10:55 am | Patricia Clark, University of Notre Dame (S5) Off to a great start: Impact of early intermediates on protein folding success |
| 11:30 am | George Makhatadze, RPI (S6) Effects of High Hydrostatic Pressure on the Stability and Function of Biomacromolecules |
| 12:05 pm | Introduction to Lunch Sponsor TA Instruments |
| 12:15 pm | Lunch Sponsored by TA Instruments Copper Top II/III |
| Stability of Viral Vectors Session Chair: Carlos Catalano, University of Colorado Colorado Ballroom | |
| 2:00 pm | Susumu Uchiyama, Osaka University (S7) Comprehensive characterizations of adeno-associated virus vectors: Analytical method development and application to AAV drug product |
| 2:35 pm | Jared Bee, RegenXBio Inc. (S8) Development of AAV Gene Therapies |
| 3:10 pm | Kevin Ausman, Spark Therapeutics (S9) Low Voltage Electron Microscopy: An Emerging Tool for AAV Characterization |
| 3:45 pm | Coffee Break |
| Amyloidosis and Protein Aggregation Session Chair: Krishna Mallela, University of Colorado Colorado Ballroom | |
| 4:15 pm | Birgit Strodel, Research Center Julich (S10) Structural Odyssey of Amyloid-β: Navigating the Conformational Landscape in Alzheimer's Pathogenesis |
| 4:50 pm | Reza Nejad Nik, University of Iowa (S11) Assessment of self-association of proteins by analysis of the loosely interacting layer detected at the proximity of a solid surface |
| 5:25 pm | Chris Roberts, University of Delaware (S12) Complex pathways for aggregation of therapeutic proteins |
| 6:00 pm | Introduction to Reception Sponsor Halo Labs |
| 6:10 pm | Colorado Beer Tasting Reception Sponsored by Halo Labs Copper Top II/III |
Wednesday, August 7
| 7:30 am | Breakfast Copper Top II/III |
| 8:30 am | Poster Setup Colorado Ballroom |
| 9:00 am | Poster Session Colorado Ballroom 9:00 am – 11:00 am - Even-numbered posters presented 11:00 am – 1:00 pm - Odd-numbered posters presented |
| 1:00 pm | Lunch Sponsored by NIIMBL Copper Top II/III |
Thursday, August 8
| 7:00 am | Breakfast Copper Top II/III |
| 8:00 am | Welcoming Comments Colorado Ballroom |
| Protein subunit vaccines Session Chair: Kevin Dahl, Spheryx Colorado Ballroom | |
| 8:05 am | Christopher B. Fox, AAHI (S13) Advanced Development of Dried Presentations of the ID93 + GLA-SE Tuberculosis Vaccine Candidate |
| 8:40 am | Johannes P.M. Langedijk, Forge Bio (S14) Efficacious vaccines through AI-guided engineering of stabilized glycoproteins |
| 9:15 am | Ted Randolph, University of Colorado (S15) Atomic Layer Deposition Techniques for Stabilization and Delivery of Virus-Based Vaccines |
| 9:50 am | Coffee Break |
| Protein – Excipient Interactions Session Chair: Christina Vessely, Biologics Consulting Colorado Ballroom | |
| 10:20 am | Raj Suryanarayanan, University of Minnesota (S16) Implications of excipient phase behavior on protein stability |
| 10:55 am | Douglas Kamen, Regeneron (S17) Evaluation of the in-use stability of monoclonal antibody IV admixtures prepared from drug products containing polysorbate 20 degraded by host cell lipases |
| 11:30 am | Atanas Koulov, Clear Solutions (S18) Surfactants in biopharmaceutical development: stability challenges and mitigation strategies |
| 12:05 pm | Introduction to Wednesday Lunch Sponsor NIIMBL |
| 12:15 pm | Introduction to Thursday Lunch Sponsor Sentry Sciences |
| 12:25 pm | Lunch Sponsored by Sentry Sciences Copper Top II/III |
| Particles in Protein Drug Products Session Chair: Andrea Hawe, Coriolis Colorado Ballroom | |
| 2:00 pm | Ewa Marszal, FDA (S19) A perspective on the history of the pharmacopeial limits for subvisible particulate matter |
| 2:35 pm | Steve Hudson, NIST (S20) Small-volume protein rheology |
| 3:10 pm | Yongchao Su, Merck (S21) Protein aggregation in high-concentration biologics: Uncovering the role of device-related stress factors |
| 3:45 pm | Coffee Break |
| Processing and Delivery of Biologics Session Chair: Amber Raines, KBI | |
| 4:15 pm | Twinkle Christian, Amgen (S23) Patient Centric Drug Development |
| 4:50 pm | Twinkle Christian, Amgen (S23) Patient Centric Drug Development |
| 5:25 pm | Wolfgang Friess, Ludwig-Maximilians University (S24) Cool & Highly Concentrated – Understanding Protein Stability And Interactions In The Frozen State As Basis For Sustainable Frozen Storage |
| 6:00 pm | Student Poster Awards & Closing Comments Colorado Ballroom |
| 6:10 pm | Closing Reception Copper Top II/III |
Evening opening reception
There will be an opening reception with buffet dinner and beverages at 7 pm on Monday, August 5.
Closing Reception
There will be a closing reception with buffet dinner and beverages at 6 pm on Thursday, August 8.
Registration
The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.
| Early Registration Fees (before July 12) | |
| Industry Registration Fee (Individual) | $1850 |
| Industry Registration Fee (Groups of 5 or more) | $1450 |
| Academic Registration Fee | $900 |
| Government Rate | $600 |
| Student/Postdoc Rate | $400 |
| Standard Registration Fees (after July 12) | |
| Industry Registration Fee | $2150 |
| Industry Registration Fee (Groups of 5 or more) | $1750 |
| Academic Registration Fee | $1200 |
| Government Rate | $750 |
| Student/Postdoc Rate | $650 |
Register Here
Cancellation Policy
Only requests for cancellation received prior to July 5th, 2024 will receive a refund, minus a $100 processing fee. If cancellation is not received by July 5th, 2024, the registration fee will be forfeited.
Contact for further information
For sponsorship opportunities and general information, please contact:
John Carpenter
303-724-6110
John.Carpenter@cuanschutz.edu
Krishna Mallela
303-724-3576
Krishna.Mallela@cuanschutz.edu
303-492-4776
theodore.randolph@colorado.edu
More information
Ground Transportation from Denver International Airport
There are two main shuttle services available from the Denver airport to the hotel in Breckenridge. And, of course, car rentals are also available at the airport.
Colorado Mountain Express
http://www.coloradomountainexpress.com
Phone: 1-800-525-6363 Reservations
Phone: 1-970-754-7433 Local
Summit Express
http://www.summitexpress.com/
Phone: 1-855-MTN-VANS | 970-668-6000
Conference Location & Hotel Room Reservation
Beaver Run Resort and Conference Center
620 Village Road Breckenridge, Colorado 80424-2115
Phone: (970) 453-6000
Phone: (800) 525-2253
Registration on the Resort website using the link for Conference special rates
Call In Reservations: Please call the Resort's Reservations Department any time at 800-525-2253 and ask for the “2024 Colorado Protein Stability Conference” group rates.
Also, please note that the Conference room block will be held until July 5, 2024. After that date, the group rates will still be honored, if rooms are available. However, because the Resort often sells out in the summer, please make your reservations early.
Special Conference Room Rates:
| Room | Rate |
| Hotel | $186.00 |
| Studio | $186.00 |
| Breckenridge Studio | $191.00 |
| Colorado Suite | $204.00 |
| Summit Suite | $216.00 |
| One Bedroom Suite | $216.00 |
| One Bedroom Suite Bldg. 4 | $216.00 |
| Two Bedroom Suite | $289.00 |
| Two Bedroom Suite Bldg. 4 | $289.00 |
| Corporate Suite | $454.00 |
Room Descriptions:
- Hotel Room features two beds, full bath, mini-fridge, microwave, small sitting area
- Studio features one queen bed, sleeper sofa, efficiency-kitchen, living/dining area
- Breckenridge Studio features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath
- Colorado Suite features queen bed, sleeper sofa, efficiency-kitchen, living/dining area, fireplace, private balcony
- Summit Suite features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath, fireplace, private balcony
- One Bedroom Suite features queen bed, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony
- One Bedroom Suite Building 4 features queen bed, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony
- Two Bedroom Suite features three queen beds, sleeper sofa, two bathrooms, full kitchen, living/dining area, fireplace, private balcony
- Two Bedroom Suite Building 4 features two queen beds, sleeper sofa, two bathrooms, full kitchen, living/dining area, fireplace, private balcony
- Corporate Suite features one king bed, one queen bed, additional alcove bedding, sleeper sofa, full kitchen, living/dining area, fireplace, private balcony
Room rates do not include 19.01% Tax and Resort Fee. There is a nightly parking fee of $10.00 per vehicle, per night. There is a limit of one vehicle per bedroom.
The Resort shall have no responsibility or liability whatsoever for any descriptions or representations made to Group members regarding the Resort property, unless such descriptions or representations are approved in advance by the Resort.
Poster Session
There will be a poster session for contributed papers on the morning of Wednesday, August 7. This session will allow for further discussions of the critical issues.
Abstract Submission
Abstracts should be prepared on a single page with one-inch margins, and should include the abstract title, list of authors, affiliations, contact email of the presenting author, and the abstract text. Black and white figures can be included, but the entire abstract should be within the one-page limit. Abstracts will be reproduced as received for the proceedings of the Conference. Abstracts should be submitted online no later than July 12th, 2024.
Student Poster Competition
The Center for Pharmaceutical Biotechnology and the Conference Sponsors are proud to sponsor this competition to promote excellence in student research. The cash prizes are: $1000 for the winner, $500 for first runner-up and $250 for second runner-up.
When submitting abstracts online, students should indicate that they wish to enter the competition.
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