Protein stability is important in numerous disciplines, ranging from fundamental and applied protein biophysics to basic and medical biochemistry to pharmaceutical sciences. However, it is rare that researchers from all of the relevant areas can join together to discuss the critical issues in the field in a more relaxed setting. Since 1994, Colorado Protein Stability Conferences have provided unique opportunities for this exchange of information. The topics that will be covered during 2022 Conference include: protein structure, thermodynamic stability, folding, and dynamics; stability of AAV vectors; amyloidosis and protein aggregation; engineering protein therapeutics; protein-excipient interactions; characterization of protein particles and new advances in processing of therapeutic proteins.

The scientific sessions will consist of plenary lectures by leading researchers from both academia and pharmaceutical industry. In addition, contributed papers will be presented during a half-day poster session with ample opportunities for young investigators to network and discuss their research. To foster exchange of information, attendance will be limited to the first 200 registrants.

The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.

Sponsored by

amgen
avantor
flowcam
lilly
redshiftbio
terumo
anton-paar
cipla
halo-labs
malvern-panalytical
refeyn
sentrysciences
applied-photophysics
coriolis-pharma
jasco
pfanstiel
rheosense
umedico
astra-zeneca
datwyler
leukocare
pfizer
ten23
umoja

John Carpenter PhD

Professor Director of Business Development, University of Colorado Center for Pharmaceutical Biotechnology Co-Founder and Co-Director

Conference Schedule

Monday, August 8

7:00 pm
Opening Reception
Sponsored by Pfizer

Copper Top III

Tuesday, August 9

7:30 am
Breakfast
Sponsored by Amgen

Copper Top III
8:25 am
Krishna Mallela, University of Colorado
Welcoming Comments

Protein Structure, Stability and Dynamics - I
Session Chair: Krishna Mallela, University of Colorado

8:30 am
Eugene Shakhnovich, Harvard University 
Protein stability in cellular context
9:05 am
Gary Pielak, University of North Carolina 
Protecting dry globular proteins with tardigrade disordered proteins and sugars 
9:40 am
Sina Ghemmaghami, University of Rochester
Stabilities of ribosome-bound and soluble proteomes measured by rates of methionine oxidation
10:15 am
Coffee Break

Protein Structure, Stability and Dynamics - II
Session Chair: David Bain, University of Colorado

10:45 am
Nicholas Fitzkee, Mississippi State University
Protein Stability on Nanoparticle Surfaces
11:20 am
Susana Teixeira, University of Delaware & NIST
Protein stability under pressure: what happens when we freeze protein solutions?
11:55 am
Margaret Cheung, Pacific Northwest National Laboratory
TBA
12:30 pm
Lunch
Sponsored by Avantor

Copper Top III

Stability of Viral Vectors
Session Chair: Tom Anchordoquy, University of Colorado

1:30 pm
Susumu Uchiyama, Osaka University
Biophysical characterizations and stability assessment of AAV vectors for gene therapy
2:05 pm
Wyatt Vreeland, NIST
AAV capsid loading metrology: Full, empty, and everything in between
2:40 pm
James Matsuura, Umoja Biopharma 
Lentivirus formulations
3:15 pm
Coffee Break

Amyloidosis and Protein Aggregation
Session Chair: Carlos Catalano, University of Colorado

3:45 pm
Jeff Kuret, Ohio State University
Induction of tau fibrillation with small molecules
4:20 pm
Witold Surewicz, Case Western Reserve University
The impact of liquid-liquid phase separation on protein aggregation in neurodegenerative diseases
4:55 pm
Vito Fodera, University of Copenhagen
Structural and morphological heterogeneity in protein aggregation
6:00 pm
Colorado Beer Tasting Reception
Sponsored by Halo Labs
Copper Top III

Wednesday, August 10

7:30 am
Breakfast
Sponsored by AstraZeneca

Copper Top III
9:00 am

Poster Session

9:00 am - 11:00 am Even-numbered posters

11:00am - 1:00pm Odd-numbered posters 

1:00 pm
Lunch
Copper Top III

Thursday, August 11

7:30 am
Breakfast
Copper Top III

Engineering Better Protein Therapeutics
Session Chair: Kevin Dahl, Particlese LLC

8:30 am
Pete Tessier, University of Michigan
Selecting and engineering antibodies with drug-like colloidal properties 
9:05 am
Hristo Svilenov, Ghent University
The ABC’s of making stable antibodies with ultra-long complementarity-determining regions 
9:40 am
Krishna Mallela, University of Colorado
Structure & stability of a long-acting human growth hormone
10:15 am
Coffee Break

Protein – Excipient Interactions
Session Chair: Andrea Hawe, Coriolis

10:45 am
Klaus Wuchner, Johnson & Johnson
Industry perspective on polysorbates as stabilizers for biopharmaceutical products
11:20 am
Björn Boll, Ten23 Health
Vial vs. Syringe – Discriminating Particulate Contamination from Silicone Oil
11:55 am
Ian Roy, Johnson & Johnson
Formulation and Development Strategies for High Concentration (>200mg/ml) Drug Products 
12:30 pm
Lunch
Copper Top II and Copper Top III

Particles in Protein Drug Products
Session Chair: Amber Raines, KBI

1:30 pm
Theodore Randolph, University of Colorado Boulder
Identification of The Culprits: Facial Recognition Algorithms to Analyze Protein Aggregates Formed in Containers and During Fill-finish Operations
2:05 pm
Tim Menzen, Coriolis
Analysis of particles in biopharmaceuticals: Case studies from protein-, virus-, and cells-based products
2:40 pm
Merry Christie, Voisin Consulting Life Sciences
Regulatory expectations for control of aggregates and particles
3:15 pm
Coffee Break

Processing and Delivery of Therapeutic Proteins
Session Chair: Chris Vessely, Biologics Consultants

3:50 pm
Sreedhara Alavattam, Genentech
Closed system transfer devices (CSdivs) – A solution looking for a problem
4:20 pm
Arezoo Ardekani, Purdue University
Modeling slosh dynamics and cavitation in autoinjectors
4:55 pm
Wolfgang Friess, Ludwig-Maximilians University
Proteins on the rack; protein particle formation upon peristaltic pumping
6:00 pm
Closing Reception
Copper Top III

Evening opening reception

There will be an opening reception with buffet dinner and beverages at 7 pm on Monday, August 8.

Closing Reception

There will be a closing reception with buffet dinner and beverages at 6:00 pm on Thursday, August 11.

Registration

The registration fee covers conference registration, abstract booklet, breakfast and lunch each day, morning and afternoon coffee breaks, and opening and closing receptions with buffet dinner and beverages.

Early Registration Fees (before July 8)
Industry Registration Fee (Individual)$1850
Industry Registration Fee (Groups of 5 or more)$1450
Academic Registration Fee$900
Government Rate$600
Student/Postdoc Rate$400
Standard Registration Fees (after July 8)
Industry Registration Fee$2150
Industry Registration Fee (Groups of 5 or more)$1750
Academic Registration Fee$1200
Government Rate$750
Student/Postdoc Rate$650

Cancellation Policy

Only requests for cancellation received prior to July 8th, 2022 will receive a refund, minus a $100 processing fee. If cancellation is not received by July 8th, 2022, the registration fee will be forfeited.

Contact for further information

For sponsorship opportunities and general information, please contact:

Krishna Mallela
+1 303-724-3576
Krishna.Mallela@cuanschutz.edu

John Carpenter
+1 303-724-6110
John.Carpenter@cuanschutz.edu

More information

Ground Transportation from Denver International Airport

There are two main shuttle services available from the Denver airport to the hotel in Breckenridge. And, of course, car rentals are also available at the airport.

Colorado Mountain Express
http://www.coloradomountainexpress.com
Phone: 1-800-525-6363 Reservations
Phone: 1-970-754-7433 Local

Summit Express
http://www.summitexpress.com/
Phone: 1-855-MTN-VANS | 970-668-6000

Conference Location & Hotel Room Reservation

Beaver Run Resort and Conference Center
620 Village Road Breckenridge, Colorado 80424-2115
Phone: (970) 453-6000
Phone: (800) 525-2253
Registration on the Resort website using the link for Conference special rates
Call In Reservations: Please call the Resort's Reservations Department any time at 800-525-2253 and ask for the “2022 Colorado Protein Stability Conference” group rates.

Also, please note that the Conference room block will be held until July 1st 2022. After that date, the group rates will still be honored, if rooms are available. However, because the Resort often sells out in the summer, please make your reservations early.

Special Conference Room Rates:

RoomRate
Hotel$159.00
Deluxe Studio$159.00
Breckenridge Studio$169.00
One Bedroom Suite$185.00
Summit Suite$185.00
Colorado Suite$175.00
One Bedroom Suite Bldg. 4$185.00
Two Bedroom Suite$245.00
Two Bedroom Suite Bldg. 4$245.00
Corporate Suite$385.00
Three Bedroom Suite$385.00
Four Bedroom Suite$475.00

Room Descriptions:

  • Hotel Room features two beds, full bath, small sitting area
  • Deluxe Studio features queen bed, sleeper sofa, mini-kitchen, spa tub
  • Breckenridge Studio features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath
  • Summit Suite features one queen bed, sleeper sofa, upgraded efficiency kitchen, living/dining area, remodeled bath, fireplace, private balcony
  • Colorado Suite features queen bed, sleeper sofa, mini-kitchen, spa tub, fireplace, private balcony
  • One Bedroom Suite features queen bed, sleeper sofa, full kitchen, fireplace, private balcony
  • One Bedroom Premium Suite features queen bed, sleeper sofa, full kitchen, fireplace, spa tub, private balcony
  • Two Bedroom Suite features three queen beds, sleeper sofa, full kitchen, fireplace, private balcony
  • Two Bedroom Premium Suite features two queen beds, sleeper sofa, full kitchen, fireplace, spa tub, private balcony
  • Corporate Suite features two queen beds, additional alcove bedding, sleeper sofa, full kitchen, fireplace, spa tub, private balcony
  • Three Bedroom Suite features various bedding, sleeper sofa, full kitchen, fireplace, private balcony
  • Four Bedroom Suite features various bedding, sleeper sofa, full kitchen, fireplace, private balcony

Room rates do not include 18.45% Tax and Resort Fee.

The Resort shall have no responsibility or liability whatsoever for any descriptions or representations made to Group members regarding the Resort property, unless such descriptions or representations are approved in advance by the Resort.

Poster Session

There will be a poster session for contributed papers on the morning of Wednesday, August 10. This session will allow for further discussions of the critical issues.

Abstract Submission

Abstracts should be prepared on a single page with one-inch margins. Abstracts will be reproduced as received for the proceedings of the Conference. Abstracts should be submitted online no later than July 8th, 2022.

Student Poster Competition

The Center for Pharmaceutical Biotechnology and the Conference Sponsors are proud to sponsor this competition to promote excellence in student research. The cash prizes are: $1000 for the winner, $500 for first runner-up and $250 for second runner-up.

When submitting abstracts online, students should indicate that they wish to enter the competition.