Department Faculty

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Research Focus: Cancer Biology Cancer Pharmacology Warfare vesicants

Research Focus: Exploiting exosome biology Immune response to nanoparticle administration Lyophilization and stability Nanoparticle-mediated gene delivery Small molecule formulation

Research Focus: Antiviral drug pharmacokinetic-pharmacodynamic relationships in humans New assays for drug/metabolite quantification in unique compartments in humans Using drug concentrations to assess adherence to antiviral therapies

Research Focus: Cardiovascular Diseases Clinical Pharmacogenomics Heart Transplantation

Research Focus: Biophysical characterization of therapeutic macromolecules Mechanisms of transcriptional regulation Thermodynamics of protein-protein and protein-DNA interactions

Research Focus: biomarkers drug-drug interactions HIV pediatrics Pharmacokinetics pregnant women tuberculosis

Research Focus: Bladder Cancer Chronic kidney disease of unknown origin (CKDu) Inflammation and immune responses to particulates Mast cells and allergy Nanomedicine and Nanosafety

Research Focus: Assembly and maturation of viral capsids Molecular mechanisms of viral DNA packaging motors Physical Virology Viral capsids as designer nanoparticles for therapeutic and diagnostic (theranostic) applications

Research Focus: CAR T and engineered T cell therapies of autoimmune diseases Mechanisms of T cell mediated metal hypersensitivities Mechanisms of T cell recognition of autoantigens in Type 1 diabetes and RA Redox signaling and drug design in the immune diseases and infectious diseases

Research Focus: Autoantigen discovery in autoimmune diseases Mass spectrometry Pathogenesis of Type 1 Diabetes Post-translational modifications T cell immunology

Research Focus: Mechanisms of alcoholic liver disease Metabolic dysregulation of liver and kidney function Regulatory nature of sirtuin activity and protein acetylation Utilizing mass spectrometry to investigate proteomics & post-translational modifications

Research Focus: Discovery and Translation of Novel Treatment Approaches to Kidney Diseases In Vivo and In Vitro Drug Metabolism and Transport in Kidney Nephrotoxicity / Biomarkers Pharmacokinetics/Pharmacodynamics/Pharmacogenomics

Research Focus: Nanomedicines for drug delivery gene delivery and imaging Novel drug delivery systems: Nanoparticles microparticles and implants. Novel therapies for diabetic retinopathy macular degeneration and cancers. Ocular respiratory and brain drug discovery delivery and development

Research Focus: Cancer Pharmacology of Natural Products Public Science Communication Science and Medical Journalism

Research Focus: Drug Design Drug Mechanism(s) of Action HTS/HCS Drug Discovery In vitro and In vivo Pharmacokinetics and Toxicology In vitro and In vivo Pharmacology Molecular and Cancer Biology Organic and Medicinal Chemistry

Research Focus: cytochrome P450 enzymes drug metabolism and disposition enzymology Pharmacokinetics

Research Focus: 2D NMR spectroscopy of antibody therapeutics Biophysical characterization of protein vaccine stability and aggregation Structure stability and aggregation of protein drug substances and drug products Structure-function-disease analysis of dystrophin and muscular dystrophy

Research Focus: Complement-mediated tissue damage Extracellular vesicles and organ-organ crosstalk Immunotherapy and natural immunosuppression Innate immunity and chronic liver diseases

Research Focus: Environmental causes of neuronal injury Mitochondrial (dys)function and oxidative stress in epilepsy and neurodegeneration Neuroinflammation and redox signaling Redox-based small molecule therapeutics

Research Focus: Ecological Roles of Natural Products Host-Microbiome-Environment Interactions Mass Spectrometry Tools for Microbial Systems

Research Focus: Behavioral responses to alcohol Quantitative RNA sequencing Systems genetics

Research Focus: Chemical synthesis of heterocyclic compounds Computational-based design of novel small molecules Disrupting drug resistance mechanisms in cancer (DNA damage response) Targeting adaptive proteins and pathways in hypoxia (metabolic reprogramming)

Research Focus: Metabolomics lipidomics and proteomics Novel informatics strategies applied to metabolomics Nutrimetabolomics Role of oxylipins in inflammatory immune and lung disease Understanding role of host:microbiome metabolism in health and disease

Research Focus: Environmental causes of neurodegeneration e.g. maneb exposure Metabolic consequences of mitochondrial dysfunction Proteostasis and neurodegeneration Thiol redox dysregulation in mechanisms of toxicity

Research Focus: Genetics of substance use disorders Multi-omics data integration Statistical methods and bioinformatics techniques for studying complex genetic traits Transcriptomics and systems genetics

Research Focus: Immunology and nanoformulations/drug delivery systems Molecular biology immunology and nanotechnology

Research Focus: Cells as carriers of drugs and diagnostics Immune recognition of nanoparticles Isolation of biomarkers and cells from bulk fluids