Michael Wempe

Michael Wempe PhD

Associate Research Professor Medicinal Chemistry Core Facility Director
  • Department of Pharmaceutical Sciences

Email Address:michael.wempe@cuanschutz.edu

Primary Phone:303-724-8982

Mailing Address:
  • CU Anschutz

Pharmacy and Pharmaceutical Sciences Building

12850 East Montview Boulevard

Second Floor Room 2105

Aurora, CO 80045

My laboratory uses chemical synthesis (organic and bio-organic) to produce known and novel compounds which are subsequently screened (in vitro) for their biological activity. Drug oral bioavailability may be influenced by low solubility, intrinsic instability, low membrane permeability, high first pass metabolism, and/or active excretion across the small intestine back into the intestinal lumen via efflux pumps.

Consequently, we are interested in and conduct fundamental research in drug metabolism, pharmacokinetics, and toxicity. 'Research' activities include: i) Medicinal Chemistry - rational drug design and Structure-Activity Relationship (SAR) elucidation; ii) computational chemistry; iii) developing novel technology to improve drug oral bioavailability and iv) identifying new bio-analytical methodology.

Education, Licensure & Certifications

  • BA, Hanover College; Hanover IN (Liberal Arts, Chemistry major)
  • MS Miami University, Oxford, Ohio, (Organic Chemistry) 
  • PhD Miami University, Oxford, Ohio, (Organic Chemistry) 
  • Post-Doctoral Fellow, University of Rochester Medical School, Rochester, NY (Pharmacology) and 
  • Physiology and Environmental Sciences (Toxicity)